Next Article in Journal
Curcugreen Treatment Prevented Splenomegaly and Other Peripheral Organ Abnormalities in 3xTg and 5xFAD Mouse Models of Alzheimer’s Disease
Next Article in Special Issue
DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration
Previous Article in Journal
Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-κB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKKβ/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation
Previous Article in Special Issue
Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
Article

Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury

1
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy
2
Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy
3
Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Via Consolare Valeria, 98125 Messina, Italy
4
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Rosalba Siracusa and Vittorio Calabrese share senior authorship.
Academic Editor: Domenico Nuzzo
Antioxidants 2021, 10(6), 898; https://doi.org/10.3390/antiox10060898
Received: 23 April 2021 / Revised: 21 May 2021 / Accepted: 29 May 2021 / Published: 2 June 2021
Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments. TBI has been shown to be a risk factor for neurodegeneration which can lead to Parkinson’s disease (PD) for example. In this study, we wanted to explore the development of PD-related pathology in the context of an experimental model of TBI and the potential ability of Coriolus versicolor and Hericium erinaceus to prevent neurodegenerative processes. Traumatic brain injury was induced in mice by controlled cortical impact. Behavioral tests were performed at various times: the animals were sacrificed 30 days after the impact and the brain was processed for Western blot and immunohistochemical analyzes. After the head injury, a significant decrease in the expression of tyrosine hydroxylase and the dopamine transporter in the substantia nigra was observed, as well as significant behavioral alterations that were instead restored following daily oral treatment with Hericium erinaceus and Coriolus versicolor. Furthermore, a strong increase in neuroinflammation and oxidative stress emerged in the vehicle groups. Treatment with Hericium erinaceus and Coriolus versicolor was able to prevent both the neuroinflammatory and oxidative processes typical of PD. This study suggests that PD-related molecular events may be triggered on TBI and that nutritional fungi such as Hericium erinaceus and Coriolus versicolor may be important in redox stress response mechanisms and neuroprotection, preventing the progression of neurodegenerative diseases such as PD. View Full-Text
Keywords: brain trauma; neurodegeneration; neuroinflammation; oxidative stress; mushrooms brain trauma; neurodegeneration; neuroinflammation; oxidative stress; mushrooms
Show Figures

Figure 1

MDPI and ACS Style

D’Amico, R.; Trovato Salinaro, A.; Fusco, R.; Cordaro, M.; Impellizzeri, D.; Scuto, M.; Ontario, M.L.; Lo Dico, G.; Cuzzocrea, S.; Di Paola, R.; Siracusa, R.; Calabrese, V. Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury. Antioxidants 2021, 10, 898. https://doi.org/10.3390/antiox10060898

AMA Style

D’Amico R, Trovato Salinaro A, Fusco R, Cordaro M, Impellizzeri D, Scuto M, Ontario ML, Lo Dico G, Cuzzocrea S, Di Paola R, Siracusa R, Calabrese V. Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury. Antioxidants. 2021; 10(6):898. https://doi.org/10.3390/antiox10060898

Chicago/Turabian Style

D’Amico, Ramona, Angela Trovato Salinaro, Roberta Fusco, Marika Cordaro, Daniela Impellizzeri, Maria Scuto, Maria L. Ontario, Gianluigi Lo Dico, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, and Vittorio Calabrese. 2021. "Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury" Antioxidants 10, no. 6: 898. https://doi.org/10.3390/antiox10060898

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop