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Systematic Review

Coenzyme Q10 and Male Infertility: A Systematic Review

Division of Endocrinology and Metabolic Diseases, Umberto I Hospital, Via Conca 71, 60126 Ancona, Italy
Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Tronto 10/A, 60126 Ancona, Italy
Author to whom correspondence should be addressed.
Academic Editor: Jesús R. Huertas
Antioxidants 2021, 10(6), 874;
Received: 22 April 2021 / Revised: 24 May 2021 / Accepted: 27 May 2021 / Published: 30 May 2021
(This article belongs to the Special Issue Health Effects of Coenzyme Q10)
Infertility affects 15% of couples worldwide. A male factor is involved in 50% of cases. The etiology of male infertility is poorly understood, but there is evidence for a strong association between oxidative stress (OS) and poor seminal fluid quality. For this reason, therapy with antioxidants is one of the cornerstones of empirical treatment of male infertility. Coenzyme Q10 (CoQ10)—an essential cofactor for energy production with major antioxidant properties—is commonly used to support spermatogenesis in idiopathic male infertility. This systematic review aims to elucidate the usefulness of CoQ10 supplementation in the treatment of male infertility, particularly with regard to semen quality assessed by conventional and advanced methods, and pregnancy rates. All studies report a beneficial effect of CoQ10 supplementation on semen parameters, although randomized controlled trials are a minority. Moreover, the optimal dosage of CoQ10 or how it can be combined with other antioxidant molecules to maximize its effect is unknown. However, CoQ10 is still one of the most promising molecules to treat idiopathic male infertility and warrants further investigation. View Full-Text
Keywords: Coenzyme Q10; antioxidants; oxidative stress; male infertility; idiopathic oligoasthenozoospermia Coenzyme Q10; antioxidants; oxidative stress; male infertility; idiopathic oligoasthenozoospermia
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MDPI and ACS Style

Salvio, G.; Cutini, M.; Ciarloni, A.; Giovannini, L.; Perrone, M.; Balercia, G. Coenzyme Q10 and Male Infertility: A Systematic Review. Antioxidants 2021, 10, 874.

AMA Style

Salvio G, Cutini M, Ciarloni A, Giovannini L, Perrone M, Balercia G. Coenzyme Q10 and Male Infertility: A Systematic Review. Antioxidants. 2021; 10(6):874.

Chicago/Turabian Style

Salvio, Gianmaria, Melissa Cutini, Alessandro Ciarloni, Lara Giovannini, Michele Perrone, and Giancarlo Balercia. 2021. "Coenzyme Q10 and Male Infertility: A Systematic Review" Antioxidants 10, no. 6: 874.

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