Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex

Ogawa, Shigesaburo; Shinkawa, Mai; Hirase, Ryuji; Tsubomura, Taro; Iuchi, Katsuya; Hara, Setsuko

doi:10.3390/antiox10030490

Open AccessArticle

Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex

by

Shigesaburo Ogawa

^1,*

,

Mai Shinkawa

¹,

Ryuji Hirase

²,

Taro Tsubomura

¹,

Katsuya Iuchi

^1,*

and

Setsuko Hara

¹

Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, Japan

²

Hyogo Prefectural Institute of Technology, 3-1-12 Yukihira-cho, Suma, Kobe 654-0037, Japan

^*

Authors to whom correspondence should be addressed.

Antioxidants 2021, 10(3), 490; https://doi.org/10.3390/antiox10030490

Submission received: 4 March 2021 / Revised: 17 March 2021 / Accepted: 18 March 2021 / Published: 20 March 2021

(This article belongs to the Collection Advances in Antioxidant Ingredients from Natural Products)

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Abstract

Development of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was developed, directed toward aqua-related biological applications. Not only β-CD, but also γ-CD, tended to form a water-insoluble aggregate with Toc in aqueous media. The aggregated vehicle, in particular the γ-CD-added system, showed a remarkable sustained effect because of slow dynamics. Furthermore, a prominent cytoprotective effect by the γ-CD–Toc vehicle under the oxidative stress condition was confirmed. Thus, the novel vitamin E vehicle motif using γ-CD as a stabilizer was proposed, widening the usability of Toc for biological applications.

Keywords: vitamin E; γ-cyclodextrin; vehicle; radical scavenging; oxidative stress; cell viability

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MDPI and ACS Style

Ogawa, S.; Shinkawa, M.; Hirase, R.; Tsubomura, T.; Iuchi, K.; Hara, S. Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex. Antioxidants 2021, 10, 490. https://doi.org/10.3390/antiox10030490

AMA Style

Ogawa S, Shinkawa M, Hirase R, Tsubomura T, Iuchi K, Hara S. Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex. Antioxidants. 2021; 10(3):490. https://doi.org/10.3390/antiox10030490

Chicago/Turabian Style

Ogawa, Shigesaburo, Mai Shinkawa, Ryuji Hirase, Taro Tsubomura, Katsuya Iuchi, and Setsuko Hara. 2021. "Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex" Antioxidants 10, no. 3: 490. https://doi.org/10.3390/antiox10030490

APA Style

Ogawa, S., Shinkawa, M., Hirase, R., Tsubomura, T., Iuchi, K., & Hara, S. (2021). Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex. Antioxidants, 10(3), 490. https://doi.org/10.3390/antiox10030490

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Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex

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