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Dietary Anti-Aging Polyphenols and Potential Mechanisms

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Department of Human Sciences, Tennessee State University, Nashville, TN 37209, USA
Department of Biology, University of North Carolina, Greensboro, NC 27402, USA
Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USA
Author to whom correspondence should be addressed.
Academic Editors: Gunter Peter Eckert and Uwe Wenzel
Antioxidants 2021, 10(2), 283;
Received: 17 December 2020 / Revised: 8 February 2021 / Accepted: 9 February 2021 / Published: 13 February 2021
(This article belongs to the Special Issue Dietary Antioxidants for Modulating the Aging Processes)
For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, and decreasing morbidities. With the assistance of basic research investigating the potential mechanisms, it has become clear that the beneficial effects of plant-based foods are mainly due to the large amount of bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies in humans have supported that the supplementation of polyphenols have various health-promoting effects, especially in the elderly population. In vitro examinations on the anti-aging mechanisms of polyphenols have been widely performed, using different types of natural and synthetic phenolic compounds. The aim of this review is to critically evaluate the experimental evidence demonstrating the beneficial effects of polyphenols on aging-related diseases. We highlight the potential anti-aging mechanisms of polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, and promoting mitochondrial function. While the trends on utilizing polyphenols in preventing aging-related disorders are getting growing attention, we suggest the exploration of the beneficial effects of the combination of multiple polyphenols or polyphenol-rich foods, as this would be more physiologically relevant to daily life. View Full-Text
Keywords: polyphenol; aging; antioxidant; cellular senescence polyphenol; aging; antioxidant; cellular senescence
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MDPI and ACS Style

Luo, J.; Si, H.; Jia, Z.; Liu, D. Dietary Anti-Aging Polyphenols and Potential Mechanisms. Antioxidants 2021, 10, 283.

AMA Style

Luo J, Si H, Jia Z, Liu D. Dietary Anti-Aging Polyphenols and Potential Mechanisms. Antioxidants. 2021; 10(2):283.

Chicago/Turabian Style

Luo, Jing, Hongwei Si, Zhenquan Jia, and Dongmin Liu. 2021. "Dietary Anti-Aging Polyphenols and Potential Mechanisms" Antioxidants 10, no. 2: 283.

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