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Article

Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study

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Clinical Chemistry, CHU of Liège, Sart Tilman, 4000 Liège, Belgium
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Toxicology Department, CHU of Liège, Sart Tilman, 4000 Liège, Belgium
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Department of Cardiovascular Surgery, CHU of Liège, Sart Tilman, 4000 Liège, Belgium
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Service of Diabetology, Nutrition and Metabolic Diseases, CHU of Liège, Sart Tilman, 4000 Liège, Belgium
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Institut Européen des Antioxydants, 54000 Nancy, France
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Intensive Care Department, CHU of Liège, Sart Tilman, 4000 Liège, Belgium
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Biostatistics and Medico-economic Information Department, CHU of Liège, Sart Tilman, 4000 Liège, Belgium
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Author to whom correspondence should be addressed.
Academic Editors: Javier Diaz-Castro, Jorge Moreno-Fernandez and Julio Ochoa Herrera
Antioxidants 2021, 10(2), 257; https://doi.org/10.3390/antiox10020257
Received: 4 January 2021 / Revised: 2 February 2021 / Accepted: 2 February 2021 / Published: 7 February 2021
(This article belongs to the Special Issue Oxidative Stress, Inflammatory Signaling, Nutrition and COVID-19)
Background: A key role of oxidative stress has been highlighted in the pathogenesis of COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 patients hospitalized in intensive care unit (ICU). Material and Methods: Biomarkers of the systemic OSS included antioxidants (9 assays), trace elements (3 assays), inflammation markers (4 assays) and oxidative damage to lipids (3 assays). Results: Blood samples were drawn after 9 (7–11) and 41 (39–43) days of ICU stay, respectively in 3 and 6 patients. Vitamin C, thiol proteins, reduced glutathione, γ-tocopherol, β-carotene and PAOT® score were significantly decreased compared to laboratory reference values. Selenium concentration was at the limit of the lower reference value. By contrast, the copper/zinc ratio (as a source of oxidative stress) was higher than reference values in 55% of patients while copper was significantly correlated with lipid peroxides (r = 0.95, p < 0.001). Inflammatory biomarkers (C-reactive protein and myeloperoxidase) were significantly increased when compared to normals. Conclusions: The systemic OSS was strongly altered in critically ill COVID-19 patients as evidenced by increased lipid peroxidation but also by deficits in some antioxidants (vitamin C, glutathione, thiol proteins) and trace elements (selenium). View Full-Text
Keywords: COVID-19; oxidative stress; critical care; vitamin C; lipid peroxides COVID-19; oxidative stress; critical care; vitamin C; lipid peroxides
MDPI and ACS Style

Pincemail, J.; Cavalier, E.; Charlier, C.; Cheramy–Bien, J.-P.; Brevers, E.; Courtois, A.; Fadeur, M.; Meziane, S.; Goff, C.L.; Misset, B.; Albert, A.; Defraigne, J.-O.; Rousseau, A.-F. Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study. Antioxidants 2021, 10, 257. https://doi.org/10.3390/antiox10020257

AMA Style

Pincemail J, Cavalier E, Charlier C, Cheramy–Bien J-P, Brevers E, Courtois A, Fadeur M, Meziane S, Goff CL, Misset B, Albert A, Defraigne J-O, Rousseau A-F. Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study. Antioxidants. 2021; 10(2):257. https://doi.org/10.3390/antiox10020257

Chicago/Turabian Style

Pincemail, Joël, Etienne Cavalier, Corinne Charlier, Jean-Paul Cheramy–Bien, Eric Brevers, Audrey Courtois, Marjorie Fadeur, Smail Meziane, Caroline L. Goff, Benoît Misset, Adelin Albert, Jean-Olivier Defraigne, and Anne-Françoise Rousseau. 2021. "Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study" Antioxidants 10, no. 2: 257. https://doi.org/10.3390/antiox10020257

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