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Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation

The Role of NRF2 in Mycobacterial Infection

Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Ibaraki, Japan
Author to whom correspondence should be addressed.
These authors contributed equally: Masashi Matsuyama and Mizu Nonaka.
Academic Editors: Wael El-Rifai, Hye-Youn Cho and Steven R. Kleeberger
Antioxidants 2021, 10(12), 1861;
Received: 3 September 2021 / Revised: 11 November 2021 / Accepted: 22 November 2021 / Published: 23 November 2021
(This article belongs to the Special Issue NRF2 in Health and Diseases)
The incidence of pulmonary nontuberculous mycobacterial (NTM) infection is increasing worldwide, and its clinical outcomes with current chemotherapies are unsatisfactory. The incidence of tuberculosis (TB) is still high in Africa, and the existence of drug-resistant tuberculosis is also an important issue for treatment. To discover and develop new efficacious anti-mycobacterial treatments, it is important to understand the host-defense mechanisms against mycobacterial infection. Nuclear erythroid 2 p45-related factor-2 (NRF2) is known to be a major regulator of various antioxidant response element (ARE)-driven cytoprotective gene expressions, and its protective role has been demonstrated in infections. However, there are not many papers or reviews regarding the role of NRF2 in mycobacterial infectious disease. Therefore, this review focuses on the role of NRF2 in the pathogenesis of Mycobacterium tuberculosis and Mycobacterium avium infection. View Full-Text
Keywords: ROS; NRF2; ARE; TB; NTM; IFN-γ; HO-1; NRAMP1 ROS; NRF2; ARE; TB; NTM; IFN-γ; HO-1; NRAMP1
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MDPI and ACS Style

Matsuyama, M.; Nonaka, M.; Nakajima, M.; Morishima, Y.; Ishii, Y.; Hizawa, N. The Role of NRF2 in Mycobacterial Infection. Antioxidants 2021, 10, 1861.

AMA Style

Matsuyama M, Nonaka M, Nakajima M, Morishima Y, Ishii Y, Hizawa N. The Role of NRF2 in Mycobacterial Infection. Antioxidants. 2021; 10(12):1861.

Chicago/Turabian Style

Matsuyama, Masashi, Mizu Nonaka, Masayuki Nakajima, Yuko Morishima, Yukio Ishii, and Nobuyuki Hizawa. 2021. "The Role of NRF2 in Mycobacterial Infection" Antioxidants 10, no. 12: 1861.

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