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Article

Antioxidant Effect of Lycium barbarum Leaf through Inflammatory and Endoplasmic Reticulum Stress Mechanism

1
Department of Food and Nutrition, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
2
Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Korea
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(1), 20; https://doi.org/10.3390/antiox10010020
Received: 26 November 2020 / Revised: 18 December 2020 / Accepted: 19 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Antioxidants of Natural Product)
Although the prevalence and incidence of inflammatory bowel disease (IBD), a defective immune response of the gastrointestinal tract, has been increasing in North America and Western Europe, recent studies have shown that this disease is also increasing rapidly in Asia. Several studies have been searching for functional foods that can prevent or reduce IBD symptoms because the drug treatments for IBD are expensive with complications. Genome-Wide Association Study (GWAS), an observational study of a genome-wide set of genetic variants in different individuals, showed that endoplasmic reticulum (ER) stress is one of the causes of IBD. Previously, we reported the effects of Lyciumbarbarum fruit and this study investigated the effects of Lycium barbarum leaf (LL) on inflammation and ER stress of the intestine. The paracellular permeability, antioxidant, and anti-inflammatory response were measured on polarized Caco-2 cells. The ER stress pathway and pro-inflammatory cytokines were evaluated on MEF-knockout cell lines, and on the intestines of the mice fed a high-fat diet with lipopolysaccharide-induced inflammation. Our data showed that the LL pretreatment strengthened the tight junction integrity and reduced NO production both in the presence and in the absence of inflammation. Furthermore, LL inhibited ER stress and inflammation via IRE1α and XBP1 in vitro as well as in the inflamed intestines of mice, highlighting the antioxidant and anti-inflammatory function of LL in an IRE1α-XBP1-dependent manner. View Full-Text
Keywords: Lycium barbarum; Goji berry; antioxidant; anti-inflammatory; ER stress Lycium barbarum; Goji berry; antioxidant; anti-inflammatory; ER stress
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MDPI and ACS Style

Lee, S.R.; An, M.-Y.; Hwang, H.-J.; Yoon, J.-G.; Cho, J.A. Antioxidant Effect of Lycium barbarum Leaf through Inflammatory and Endoplasmic Reticulum Stress Mechanism. Antioxidants 2021, 10, 20. https://doi.org/10.3390/antiox10010020

AMA Style

Lee SR, An M-Y, Hwang H-J, Yoon J-G, Cho JA. Antioxidant Effect of Lycium barbarum Leaf through Inflammatory and Endoplasmic Reticulum Stress Mechanism. Antioxidants. 2021; 10(1):20. https://doi.org/10.3390/antiox10010020

Chicago/Turabian Style

Lee, So R., Mi-Yeong An, Hye-Jeong Hwang, Ju-Gyeong Yoon, and Jin A. Cho. 2021. "Antioxidant Effect of Lycium barbarum Leaf through Inflammatory and Endoplasmic Reticulum Stress Mechanism" Antioxidants 10, no. 1: 20. https://doi.org/10.3390/antiox10010020

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