Evaluation of Postnatal Sedation in Full-Term Infants
AbstractProlonged sedation in infants leads to a high incidence of physical dependence. We inquired: (1) “How long does it take to develop physical dependence to sedation in previously naïve full-term infants without known history of neurologic impairment?” and (2) “What is the relationship between length of sedation to length of weaning and hospital stay?”. The retrospective study included full-term patients over a period of one year that were <1 year of age and received opioids and benzodiazepines >72 hours. Quantification of fentanyl, morphine, and midazolam were compared among three time periods: <5 days, 5–30 days, and >30 days using t-test or one-way analysis of variance. Identified full-term infants were categorized into surgical (14/44) or medical (10/44) groups, while those with neurological involvement (20/44) were excluded. Physical dependence in full-term infants occurred following sedation ≥5 days. Infants with surgical disease received escalating doses of morphine and midazolam when administered >30 days. A positive association between length of sedation and weaning period was found for both respiratory (p < 0.01) and surgical disease (p = 0.012) groups, while length of sedation is related to hospital stay for the respiratory (p < 0.01) but not the surgical disease group (p = 0.1). Future pharmacological directions should lead to standardized sedation protocols and evaluate patient neurocognitive outcomes. View Full-Text
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Solodiuk, J.C.; Jennings, R.W.; Bajic, D. Evaluation of Postnatal Sedation in Full-Term Infants. Brain Sci. 2019, 9, 114.
Solodiuk JC, Jennings RW, Bajic D. Evaluation of Postnatal Sedation in Full-Term Infants. Brain Sciences. 2019; 9(5):114.Chicago/Turabian Style
Solodiuk, Jean C.; Jennings, Russell W.; Bajic, Dusica. 2019. "Evaluation of Postnatal Sedation in Full-Term Infants." Brain Sci. 9, no. 5: 114.
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