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A Review of Functional and Structural Neurobiology of the Action Observation Network in Autism Spectrum Disorder and Developmental Coordination Disorder

1
Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University Southern California, Los Angeles, CA 90089, USA
2
Brain and Creativity Institute, University Southern California, Los Angeles, CA 90089, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(4), 75; https://doi.org/10.3390/brainsci9040075
Received: 1 March 2019 / Revised: 20 March 2019 / Accepted: 22 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Brain Mechanisms of Sensory Processing Disorder)
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Abstract

Recent research has reported motor impairment similarities between children with developmental coordination disorder (DCD) and a subgroup of individuals with autism spectrum disorder (ASD). However, there is a debate as to whether DCD is a co-occurring diagnosis in individuals with ASD and motor impairments (ASDd), or if motor impairments in ASD are distinct from DCD. However, the etiology of motor impairments is not well understood in either disorder. Clarifying comorbidities in ASD is important to determine different etiopathological phenotyping clusters in ASD and to understand the variety of genetic and environmental factors that contribute to the disorder. Furthermore, this distinction has important therapeutic relevance. Here we explore the current neuroimaging findings in ASD and DCD and discusses possible neural mechanisms that underlie similarities and differences between the disorders. View Full-Text
Keywords: Autism spectrum disorder (ASD); developmental coordination disorder (DCD); action observation network (AON); functional magnetic resonance imaging (fMRI); resting state; diffusion weighted imaging (DWI) Autism spectrum disorder (ASD); developmental coordination disorder (DCD); action observation network (AON); functional magnetic resonance imaging (fMRI); resting state; diffusion weighted imaging (DWI)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kilroy, E.; Cermak, S.A.; Aziz-Zadeh, L. A Review of Functional and Structural Neurobiology of the Action Observation Network in Autism Spectrum Disorder and Developmental Coordination Disorder. Brain Sci. 2019, 9, 75.

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