Characteristics of the Uncinate Fasciculus and Cingulum in Patients with Mild Cognitive Impairment: Diffusion Tensor Tractography Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. MRI Acquisition
2.3. Neuropsychological Tests
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Control (n = 14, M/F: 5/9) | MCI (n = 16, M/F: 9/7) | p-Value | |||
---|---|---|---|---|---|
Mean | SD | Mean | SD | ||
Age, year | 66.00 | 4.95 | 71.38 | 8.61 | 0.044 * |
K-MMSE | 27.84 | 1.28 | 25.73 | 3.23 | 0.037 * |
Digit span | |||||
Forward | 7.00 | 1.15 | 6.33 | 1.45 | 0.194 |
Backward | 4.85 | 1.77 | 3.47 | 1.36 | 0.028 * |
Language | |||||
Short-BNT | 12.46 | 1.50 | 9.73 | 2.60 | 0.003 ** |
Visuospatial function | |||||
RCFT (copy score) | 33.77 | 2.95 | 26.33 | 10.87 | 0.025 * |
Memory (SVLT-E) | |||||
Immediate recall | 19.84 | 3.87 | 14.20 | 4.51 | 0.002 ** |
Delayed recall | 6.46 | 1.45 | 2.00 | 2.32 | 0.000 ** |
Frontal/Executive functions | |||||
Go-No-Go | 19.38 | 0.96 | 16.33 | 5.61 | 0.065 |
Control | MCI | p-Value | ||||
---|---|---|---|---|---|---|
Mean | SD | Mean | SD | |||
FA of Cingulum | Right | 0.54 | 0.03 | 0.52 | 0.02 | 0.106 |
Left | 0.54 | 0.02 | 0.53 | 0.02 | 0.194 | |
FA of UF | Right | 0.48 | 0.03 | 0.47 | 0.03 | 0.639 |
Left | 0.48 | 0.02 | 0.47 | 0.045 | 0.723 | |
The number of fibers of Cingulum | Right | 1251.00 | 399.19 | 907.87 | 262.37 | 0.011 * |
Left | 1217.85 | 289.94 | 983.07 | 332.48 | 0.059 | |
The number of fibers of UF | Right | 912.15 | 228.76 | 587.40 | 234.05 | 0.001 * |
Left | 590.69 | 270.43 | 434.80 | 236.15 | 0.115 |
Age | Right Cingulum | Left Cingulum | Right UF | Left UF | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
FA | The Number of Fibers | FA | The Number of Fibers | FA | The Number of Fibers | FA | The Number of Fibers | ||||
Right Cingulum | FA | r | −0.132 | - | |||||||
The number of fibers | r | −0.144 | 0.499 ** | - | |||||||
Left Cingulum | FA | r | −0.285 | 0.671 ** | 0.366 | - | |||||
The number of fibers | r | −0.126 | 0.301 | 0.415 ** | 0.236 | - | |||||
Right UF | FA | r | −0.066 | 0.434 * | 0.236 | 0.453 ** | −0.108 | - | |||
The number of fibers | r | 0.193 | 0.065 | 0.295 | −0.044 | 0.032 | −0.089 | - | |||
Left UF | FA | r | −0.230 | 0.370 | 0.219 | 0.387 ** | 0.111 | 0.647 ** | −0.162 | - | |
The number of fibers | r | −0.331 | -0.191 | 0.141 | 0.124 | −0.034 | 0.171 | 0.302 | 0.408 ** | - | |
Digit span | Forward | r | −0.287 | 0.263 | 0.119 | 0.103 | −0.174 | −0.081 | 0.305 | 0.285 | 0.116 |
Backward | r | −0.335 | 0.252 | 0.150 | 0.003 | 0.363 | −0.190 | 0.325 | 0.211 | 0.169 | |
Language | Short BNT | r | −0.359 | 0.194 | 0.384 ** | 0.013 | 0.230 | −0.058 | 0.341 | 0.249 | 0.303 |
Visuospatial function | RCFT | r | −0.322 | 0.301 | 0.378 ** | 0.200 | 0.223 | −0.014 | 0.249 | 0.269 | 0.096 |
Memory (SVLT-E) | Immediate recall | r | −0.539 ** | 0.155 | −0.013 | −0.034 | 0.223 | −0.153 | 0.248 | 0.012 | 0.109 |
Delayed recall | r | −0.145 | 0.144 | 0.161 | 0.031 | 0.207 | −0.156 | 0.424 ** | 0.067 | 0.370 | |
Frontal/Executive function | Go-no-Go | r | −0.329 | 0.369 | 0.324 | 0.174 | 0.181 | −0.070 | 0.217 | 0.198 | 0.042 |
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Park, C.-H.; Kim, S.-H.; Jung, H.-Y. Characteristics of the Uncinate Fasciculus and Cingulum in Patients with Mild Cognitive Impairment: Diffusion Tensor Tractography Study. Brain Sci. 2019, 9, 377. https://doi.org/10.3390/brainsci9120377
Park C-H, Kim S-H, Jung H-Y. Characteristics of the Uncinate Fasciculus and Cingulum in Patients with Mild Cognitive Impairment: Diffusion Tensor Tractography Study. Brain Sciences. 2019; 9(12):377. https://doi.org/10.3390/brainsci9120377
Chicago/Turabian StylePark, Chan-Hyuk, Su-Hong Kim, and Han-Young Jung. 2019. "Characteristics of the Uncinate Fasciculus and Cingulum in Patients with Mild Cognitive Impairment: Diffusion Tensor Tractography Study" Brain Sciences 9, no. 12: 377. https://doi.org/10.3390/brainsci9120377
APA StylePark, C.-H., Kim, S.-H., & Jung, H.-Y. (2019). Characteristics of the Uncinate Fasciculus and Cingulum in Patients with Mild Cognitive Impairment: Diffusion Tensor Tractography Study. Brain Sciences, 9(12), 377. https://doi.org/10.3390/brainsci9120377