Next Article in Journal
Left-Hemispheric Asymmetry for Object-Based Attention: an ERP Study
Previous Article in Journal
Obsessive Compulsive Symptoms and Psychopathological Profile in Children and Adolescents with KBG Syndrome
Previous Article in Special Issue
An Investigation of Limbs Exercise as a Treatment in Improving the Psychomotor Speed in Older Adults with Mild Cognitive Impairment
Open AccessArticle

Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?

1
Department of Methodology of Behavioral Sciences, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, Spain
2
Department of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, Spain
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(11), 314; https://doi.org/10.3390/brainsci9110314
Received: 26 September 2019 / Revised: 28 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Dementia and Cognitive Ageing)
(1) Background: Early identification of mild cognitive impairment (MCI) in people reporting subjective cognitive complaints (SCC) and the study of progression of cognitive decline are important issues in dementia research. This paper examines whether empirically derived procedures predict progression from MCI to dementia. (2) Methods: At baseline, 192 participants with SCC were diagnosed according to clinical criteria as cognitively unimpaired (70), single-domain amnestic MCI (65), multiple-domain amnestic MCI (33) and multiple-domain non-amnestic MCI (24). A two-stage hierarchical cluster analysis was performed for empirical classification. Categorical regression analysis was then used to assess the predictive value of the clusters obtained. Participants were re-assessed after 36 months. (3) Results: Participants were grouped into four empirically derived clusters: Cluster 1, similar to multiple-domain amnestic MCI; Cluster 2, characterized by subjective cognitive decline (SCD) but with low scores in language and working memory; Cluster 3, with specific deterioration in episodic memory, similar to single-domain amnestic MCI; and Cluster 4, with SCD but with scores above the mean in all domains. The majority of participants who progressed to dementia were included in Cluster 1. (4) Conclusions: Cluster analysis differentiated between MCI and SCD in a sample of people with SCC and empirical criteria were more closely associated with progression to dementia than standard criteria.
Keywords: cognitive aging; mild cognitive impairment; subjective cognitive complaints; dementia; cluster analysis; Compostela aging study; screening and diagnosis cognitive aging; mild cognitive impairment; subjective cognitive complaints; dementia; cluster analysis; Compostela aging study; screening and diagnosis
MDPI and ACS Style

Picón, E.; Juncos-Rabadán, O.; Lojo-Seoane, C.; Campos-Magdaleno, M.; Mallo, S.C.; Nieto-Vietes, A.; Pereiro, A.X.; Facal, D. Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? Brain Sci. 2019, 9, 314.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop