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Erratum: Lee, J.G., et al. The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease. Brain Sciences 2019, 9(10), 285
Open AccessArticle

Paternal—but Not Maternal—Autistic Traits Predict Frontal EEG Alpha Asymmetry in Infants with Later Symptoms of Autism

1
Child Psychopathology Unit, Scientific Institute IRCCS E. Medea, Bosisio Parini, 23842 Lecco, Italy
2
Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, ON M6J 1H4, Canada
3
Bioengineering Lab, Scientific Institute IRCCS E. Medea, Bosisio Parini, 23842 Lecco, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(12), 342; https://doi.org/10.3390/brainsci9120342
Received: 21 October 2019 / Revised: 23 November 2019 / Accepted: 24 November 2019 / Published: 26 November 2019
(This article belongs to the Special Issue Advances in Autism Research)
Previous research found that the parental autism phenotype is associated with child autism spectrum disorder (ASD), even if the pathway between autistic traits in parents and child ASD is still largely unknown. Several studies investigated frontal asymmetry in alpha oscillation (FAA) as an early marker for ASD. However, no study has examined the mediational effect of FAA between parental autistic traits and child ASD symptoms in the general population. We carried out a prospective study of 103 typically developing infants and measured FAA as a mediator between both maternal and paternal autistic traits and child ASD traits. We recorded infant baseline electroencephalogram (EEG) at 6 months of age. Child ASD symptoms were measured at age 24 months by the Child Behavior Checklist 1½–5 Pervasive Developmental Problems Scale, and parental autistic traits were scored by the Autism spectrum Quotient questionnaire. The mediation model showed that paternal vs. maternal autistic traits are associated with greater left FAA which, in turn, is associated with more child ASD traits with a significant indirect effect only in female infants vs. male infants. Our findings show a potential cascade of effects whereby paternal autistic traits drive EEG markers contributing to ASD risk. View Full-Text
Keywords: autism spectrum disorder; infants; frontal EEG alpha asymmetry; early detection autism spectrum disorder; infants; frontal EEG alpha asymmetry; early detection
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MDPI and ACS Style

Riva, V.; Marino, C.; Piazza, C.; Riboldi, E.M.; Mornati, G.; Molteni, M.; Cantiani, C. Paternal—but Not Maternal—Autistic Traits Predict Frontal EEG Alpha Asymmetry in Infants with Later Symptoms of Autism. Brain Sci. 2019, 9, 342.

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