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Ten Key Insights into the Use of Spinal Cord fMRI

Centre for Neuroscience Studies, Queen’s University, Kingston, ON K7L 3N6, Canada
Department of Biomedical Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
Department of Physics, Queen’s University, Kingston, ON K7L 3N6, Canada
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(9), 173;
Received: 10 August 2018 / Revised: 29 August 2018 / Accepted: 6 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Functional Neuroimaging of the Spinal Cord)
A comprehensive review of the literature-to-date on functional magnetic resonance imaging (fMRI) of the spinal cord is presented. Spinal fMRI has been shown, over more than two decades of work, to be a reliable tool for detecting neural activity. We discuss 10 key points regarding the history, development, methods, and applications of spinal fMRI. Animal models have served a key purpose for the development of spinal fMRI protocols and for experimental spinal cord injury studies. Applications of spinal fMRI span from animal models across healthy and patient populations in humans using both task-based and resting-state paradigms. The literature also demonstrates clear trends in study design and acquisition methods, as the majority of studies follow a task-based, block design paradigm, and utilize variations of single-shot fast spin-echo imaging methods. We, therefore, discuss the similarities and differences of these to resting-state fMRI and gradient-echo EPI protocols. Although it is newly emerging, complex connectivity and network analysis is not only possible, but has also been shown to be reliable and reproducible in the spinal cord for both task-based and resting-state studies. Despite the technical challenges associated with spinal fMRI, this review identifies reliable solutions that have been developed to overcome these challenges. View Full-Text
Keywords: spinal cord; fMRI; human; animal; methods; analysis; review spinal cord; fMRI; human; animal; methods; analysis; review
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Powers, J.M.; Ioachim, G.; Stroman, P.W. Ten Key Insights into the Use of Spinal Cord fMRI. Brain Sci. 2018, 8, 173.

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