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Magnetoencephalography: Clinical and Research Practices

Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
Research and Education, W. G. “Bill” Hefner Salisbury VAMC, Salisbury, NC 28144, USA
Department of Neurology, William S Middleton Veterans Memorial Hospital, Madison, WI 53705, USA
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(8), 157;
Received: 28 June 2018 / Revised: 7 August 2018 / Accepted: 11 August 2018 / Published: 17 August 2018
Magnetoencephalography (MEG) is a neurophysiological technique that detects the magnetic fields associated with brain activity. Synthetic aperture magnetometry (SAM), a MEG magnetic source imaging technique, can be used to construct both detailed maps of global brain activity as well as virtual electrode signals, which provide information that is similar to invasive electrode recordings. This innovative approach has demonstrated utility in both clinical and research settings. For individuals with epilepsy, MEG provides valuable, nonredundant information. MEG accurately localizes the irritative zone associated with interictal spikes, often detecting epileptiform activity other methods cannot, and may give localizing information when other methods fail. These capabilities potentially greatly increase the population eligible for epilepsy surgery and improve planning for those undergoing surgery. MEG methods can be readily adapted to research settings, allowing noninvasive assessment of whole brain neurophysiological activity, with a theoretical spatial range down to submillimeter voxels, and in both humans and nonhuman primates. The combination of clinical and research activities with MEG offers a unique opportunity to advance translational research from bench to bedside and back. View Full-Text
Keywords: magnetoencephalography; magnetic source imaging; synthetic aperture magnetometry; epilepsy magnetoencephalography; magnetic source imaging; synthetic aperture magnetometry; epilepsy
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Stapleton-Kotloski, J.R.; Kotloski, R.J.; Popli, G.; Godwin, D.W. Magnetoencephalography: Clinical and Research Practices. Brain Sci. 2018, 8, 157.

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