Next Article in Journal / Special Issue
The Role of Peripheral CNS‐Directed Antibodies in Promoting Inflammatory CNS Demyelination
Previous Article in Journal
Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson’s Disease (PD)
Previous Article in Special Issue
Evaluation of Visual-Evoked Cerebral Metabolic Rate of Oxygen as a Diagnostic Marker in Multiple Sclerosis
Open AccessReview

Contribution of the Degeneration of the Neuro-Axonal Unit to the Pathogenesis of Multiple Sclerosis

1
Department of Anatomy and Cell Biology, CMSNRC (Cameco MS Neuroscience Research Center), University of Saskatchewan, Saskatoon, SK S7N0Z1, Canada
2
Veterans Administration Medical Center, Memphis, TN 38104, USA
3
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38104, USA
4
Department of Neurology, University of Saskatchewan, Saskatoon, SK S7N0Z1, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Evanthia Bernitsas
Brain Sci. 2017, 7(6), 69; https://doi.org/10.3390/brainsci7060069
Received: 5 May 2017 / Revised: 9 June 2017 / Accepted: 14 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Pathophysiology and Imaging Diagnosis of Demyelinating Disorders)
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. In recent years, it has become more evident that neurodegeneration, including neuronal damage and axonal injury, underlies permanent disability in MS. This manuscript reviews some of the mechanisms that could be responsible for neurodegeneration and axonal damage in MS and highlights the potential role that dysfunctional heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and antibodies to hnRNP A1 may play in MS pathogenesis. View Full-Text
Keywords: multiple sclerosis; RNA binding protein; neurodegeneration; axonal damage; hnRNP A1 multiple sclerosis; RNA binding protein; neurodegeneration; axonal damage; hnRNP A1
Show Figures

Figure 1

MDPI and ACS Style

Salapa, H.E.; Lee, S.; Shin, Y.; Levin, M.C. Contribution of the Degeneration of the Neuro-Axonal Unit to the Pathogenesis of Multiple Sclerosis. Brain Sci. 2017, 7, 69.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop