Application of Artificial Intelligence Tools for Social and Psychological Enhancement of Students with Autism Spectrum Disorder: A Systematic Review
Abstract
1. Introduction
2. Methodology
3. Exclusion Stages and Criteria
4. Results
5. Settings
6. Interventions
7. Outcomes
8. Discussion
9. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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| Year | Author | Title | Country | Study Design | Sample Size | Age Group | Population Characteristics |
|---|---|---|---|---|---|---|---|
| 2020 | So et al. [26] | Effectiveness of a Robot Drama Paradigm on Joint Attention in Children with ASD | Hong Kong | Randomized controlled trial | 30 | 6–12 years | Children diagnosed with ASD |
| 2018 | Giannopulu et al. [25] | Emotional Empathy as a Mechanism of Synchronisation in Child-Robot Interaction | France and Japan | Experimental cross-cultural study | 40 | 6–15 years | Children with ASD |
| 2022 | Holeva et al. [28] | Robot-Assisted Psychoeducational Intervention for Children with ASD | Greece | Randomized controlled trial | 51 | 6–12 years | Children with ASD, IQ within normal range |
| 2022 | Gaitán-Padilla et al. [27] | Socially-Assistive Robotics for Improving Social Participation in ASD | Colombia | Non-randomized intervention study | 20 | 5–10 years | Children with ASD |
| 2023 | Ghiglino et al. [24] | Artificial Scaffolding of Social Cognition Using Humanoid Robots | Italy | Randomized controlled trial | 45 | 7–14 years | Children with ASD, moderate–high IQ |
| 2024 | Chung, Sin and Chow [20] | Robotic Intervention to Improve Social Communication in ASD | Hong Kong | Randomized controlled trial | 60 | 6–10 years | Children with ASD |
| 2024 | Silva et al. [29] | AI-Based Gaze and EEG Monitoring During Robot-Assisted Therapy | Portugal and Italy | Pilot exploratory study | 5 | 8–16 years | Children with ASD |
| 2025 | Van der Steen et al. [23] | Dog-Assisted vs. Robot Dog-Assisted Therapy in Neurodevelopmental Disorders | Netherlands | Randomized controlled trial | 65 | 6–14 years | Children with ASD and Down syndrome |
| AI Intervention Type | Outcome Domain | Key Findings | Strengths | Limitations | |||
| Humanoid robots (e.g., NAO, iCub, HUMANE, CASTOR) | Joint attention, social communication | Improvements in joint attention, social reciprocity, and emotion recognition | High engagement; structured and predictable interaction | Small samples; limited long-term follow-up | |||
| Humanoid robots (iCub) | Theory of mind | Improved theory of mind and prosocial behaviors | Use of standardized assessments | Participants are often high-functioning; limited generalizability | |||
| Non-humanoid robots (robotic dog, toy/plant robot) | Emotional regulation, empathy | Enhanced emotional attunement and affective engagement | Reduced social complexity; lower anxiety | Mixed effectiveness compared to live agents | |||
| AI sensing systems (gaze-tracking, EEG, HR/HRV) | Attention, engagement | Increased task engagement and attention during sessions | Objective, real-time measurements | Technical complexity; very small samples | |||
| AI-based cognitive applications (ToM tasks) | Social cognition | Improved social understanding in structured settings | Targeted cognitive training | Limited evidence for transfer to daily life | |||
| Study (Year) | Country/Sample | Type of Robot/AI Tool | Targeted Skills | Main Outcomes | Measurement Methods |
|---|---|---|---|---|---|
| So et al. (2020) [26] | Hong Kong/30 children | Humanoid robot (HUMANE) | Joint attention | ↑ Response to joint attention (RJA) and initiation of joint attention (IJA) | Video recordings |
| Holeva et al. (2022) [28] | Greece/51 children | NAO humanoid robot | Emotion recognition, social interaction | ↑ Psychosocial skills, better emotion recognition vs. human-only group | Therapists’ recordings |
| Ghiglino et al. (2023) [24] | Italy/45 children | iCub (humanoid) vs. Cozmo (toy robot) | Theory of mind, social cognition | iCub: ↑ Theory of mind and prosocial behaviors; Cozmo: no significant change | Standardized tests (NEPSY-II) |
| Gaitán-Padilla et al. (2022) [27] | Colombia/20 children | CASTOR humanoid robot | Social participation, imitation | ↑ maintained social skills | Therapists’ evaluations |
| Silva et al. (2024) [29] | Portugal and Italy/5 children | NAO + Gaze-tracking + EEG sensors | Attention, engagement | ↑ Overall attention but gradual decline in focus on robot | EEG data, gaze-tracking |
| Chung, Sin and Chow (2024) [20] | Hong Kong/60 children | NAO humanoid robot | Social communication | ↑ Social reciprocity and ↓ non-functional behaviors | Parent questionnaires |
| Van Der Steen et al. (2025) [23] | Netherlands/65 children (ASD + DS) | Robotic dog (WowWee CHiP) | Emotional regulation, confidence | ↑ Emotional attunement, live dog > robot dog for emotional regulation | Parent reports |
| Giannopulu et al. (2018) [25] | France and Japan/40 children | Plant robot “Pekkopa” | Emotional empathy, synchrony | ↑ Emotional synchrony with robot vs. human partner | HR and HRV sensors |
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Tsapanou, A.; Bouka, A.; Papadopoulou, A.; Vamvatsikou, C.; Mikrouli, D.; Theofila, E.; Dionysopoulou, K.; Kortseli, K.; Lytaki, P.; Spyridonidi, T.M.; et al. Application of Artificial Intelligence Tools for Social and Psychological Enhancement of Students with Autism Spectrum Disorder: A Systematic Review. Brain Sci. 2026, 16, 56. https://doi.org/10.3390/brainsci16010056
Tsapanou A, Bouka A, Papadopoulou A, Vamvatsikou C, Mikrouli D, Theofila E, Dionysopoulou K, Kortseli K, Lytaki P, Spyridonidi TM, et al. Application of Artificial Intelligence Tools for Social and Psychological Enhancement of Students with Autism Spectrum Disorder: A Systematic Review. Brain Sciences. 2026; 16(1):56. https://doi.org/10.3390/brainsci16010056
Chicago/Turabian StyleTsapanou, Angeliki, Anastasia Bouka, Angeliki Papadopoulou, Christina Vamvatsikou, Dionisia Mikrouli, Eirini Theofila, Kassandra Dionysopoulou, Konstantina Kortseli, Panagiota Lytaki, Theoni Myrto Spyridonidi, and et al. 2026. "Application of Artificial Intelligence Tools for Social and Psychological Enhancement of Students with Autism Spectrum Disorder: A Systematic Review" Brain Sciences 16, no. 1: 56. https://doi.org/10.3390/brainsci16010056
APA StyleTsapanou, A., Bouka, A., Papadopoulou, A., Vamvatsikou, C., Mikrouli, D., Theofila, E., Dionysopoulou, K., Kortseli, K., Lytaki, P., Spyridonidi, T. M., & Plotas, P. (2026). Application of Artificial Intelligence Tools for Social and Psychological Enhancement of Students with Autism Spectrum Disorder: A Systematic Review. Brain Sciences, 16(1), 56. https://doi.org/10.3390/brainsci16010056

