Electroacupuncture Reduced Fibromyalgia-Pain-like Behavior through Inactivating Transient Receptor Potential V1 and Interleukin-17 in Intermittent Cold Stress Mice Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Animals and Ethical Considerations
2.2. The Intermittent Cold Stress (ICS)-Induced Fibromyalgia (FM)-like Mice Model
2.3. Electroacupuncture (EA) and Sham EA Treatments
2.4. Behavior Test
2.5. Enzyme-Linked Immunosorbent Assay (ELISA) and Western Blot Analysis
2.6. Immunofluorescence
2.7. Statistical Analysis
3. Results
3.1. Effect of Electroacupuncture Treatment and TRPV1 Deletion on Pain-like Behavior and the Levels of Inflammatory Mediators in Fibromyalgia Model Mice
3.2. Electroacupuncture (EA) and TRPV1 Deletion (Trpv1−/−) but Not Sham EA Reduced IL-17-Related Signaling Pathways in the Somatosensory Cortex (SSC) of Mice
3.3. Electroacupuncture (EA) and TRPV1 Deletion (Trpv1−/−) but Not Sham EA Reduced IL-17-Related Signaling Pathways in the Cerebellum Lobe V (CB5) of Mice
3.4. Electroacupuncture (EA) and TRPV1 Deletion (Trpv1−/−) but Not Sham EA Reduced IL-17-Related Signaling Pathways in the Cerebellum Lobe VI (CB6) of Mice
3.5. Electroacupuncture (EA) and TRPV1 Deletion (Trpv1−/−) but Not Sham EA Reduced IL-17-Related Signaling Pathways in the Cerebellum Lobe VII (CB7) of Mice
4. Discussion
5. Conclusions
6. Limitations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Yeh, Y.-A.; Liao, H.-Y.; Hsiao, I.-H.; Hsu, H.-C.; Lin, Y.-W. Electroacupuncture Reduced Fibromyalgia-Pain-like Behavior through Inactivating Transient Receptor Potential V1 and Interleukin-17 in Intermittent Cold Stress Mice Model. Brain Sci. 2024, 14, 869. https://doi.org/10.3390/brainsci14090869
Yeh Y-A, Liao H-Y, Hsiao I-H, Hsu H-C, Lin Y-W. Electroacupuncture Reduced Fibromyalgia-Pain-like Behavior through Inactivating Transient Receptor Potential V1 and Interleukin-17 in Intermittent Cold Stress Mice Model. Brain Sciences. 2024; 14(9):869. https://doi.org/10.3390/brainsci14090869
Chicago/Turabian StyleYeh, Yu-An, Hsien-Yin Liao, I-Han Hsiao, Hsin-Cheng Hsu, and Yi-Wen Lin. 2024. "Electroacupuncture Reduced Fibromyalgia-Pain-like Behavior through Inactivating Transient Receptor Potential V1 and Interleukin-17 in Intermittent Cold Stress Mice Model" Brain Sciences 14, no. 9: 869. https://doi.org/10.3390/brainsci14090869