New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review

Barbosa, Renata Montes Garcia; Soares, Miriam Carvalho; Portela, Denise Maria Meneses Cury; Guimarães, Thiago Gonçalves; Cury, Rubens Gisbert

doi:10.3390/brainsci14070638

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New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review

by

Renata Montes Garcia Barbosa

¹,

Miriam Carvalho Soares

¹

,

Denise Maria Meneses Cury Portela

²,

Thiago Gonçalves Guimarães

¹

and

Rubens Gisbert Cury

^1,*

¹

Movement Disorders Center, Department of Neurology, School of Medicine, University of São Paulo, São Paulo 05403-010, Brazil

²

Movement Disorders Center, Department of Neurology, School of Medicine, Centro Universitário Uninovafapi (UNINOVAFAPI), Teresina 64073505, Brazil

^*

Author to whom correspondence should be addressed.

Brain Sci. 2024, 14(7), 638; https://doi.org/10.3390/brainsci14070638

Submission received: 4 June 2024 / Revised: 23 June 2024 / Accepted: 24 June 2024 / Published: 26 June 2024

(This article belongs to the Special Issue Advances in Deep Brain Stimulation for Parkinson's Disease and Other Movement Disorders)

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Abstract

Deep Brain Stimulation (DBS) is an effective treatment option for patients with dopaminergic complications of Parkinson’s disease (PD) and drug-refractory PD tremor. However, DBS and its indications can be challenging, and they are not often debated in the medical community. Through a critical narrative review, the objective of this paper is to improve the comprehension of DBS indications and help to solve the puzzle that this process can be. Proper patient selection is the first step for a good surgical outcome. In this review, then, relevant considerations are discussed, involving PD genes, PD phenotypes, indications of early stages, non-motor symptoms, neuroimaging predictors, comorbidities, and age. Individualized approaches are encouraged, including clinical and radiological factors. Social support during the whole follow-up and expectations alignment are necessary through this process and are also debated.

Keywords: deep brain stimulation; Parkinson’s disease; genetics; imaging

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MDPI and ACS Style

Barbosa, R.M.G.; Soares, M.C.; Portela, D.M.M.C.; Guimarães, T.G.; Cury, R.G. New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review. Brain Sci. 2024, 14, 638. https://doi.org/10.3390/brainsci14070638

AMA Style

Barbosa RMG, Soares MC, Portela DMMC, Guimarães TG, Cury RG. New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review. Brain Sciences. 2024; 14(7):638. https://doi.org/10.3390/brainsci14070638

Chicago/Turabian Style

Barbosa, Renata Montes Garcia, Miriam Carvalho Soares, Denise Maria Meneses Cury Portela, Thiago Gonçalves Guimarães, and Rubens Gisbert Cury. 2024. "New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review" Brain Sciences 14, no. 7: 638. https://doi.org/10.3390/brainsci14070638

APA Style

Barbosa, R. M. G., Soares, M. C., Portela, D. M. M. C., Guimarães, T. G., & Cury, R. G. (2024). New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review. Brain Sciences, 14(7), 638. https://doi.org/10.3390/brainsci14070638

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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New Perspectives of Deep Brain Stimulation Indications for Parkinson’s Disease: A Critical Review

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