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Brain Sciences
Volume 13
Issue 3
10.3390/brainsci13030395
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Article

Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study

by
Valeria Sacca
,
Nasim Maleki
,
Ya Wen
,
Sierra Hodges
and
Jian Kong
*
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 2nd Avenue, Charlestown, MA 02129, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2023, 13(3), 395; https://doi.org/10.3390/brainsci13030395
Submission received: 6 January 2023 / Revised: 11 February 2023 / Accepted: 22 February 2023 / Published: 25 February 2023
(This article belongs to the Special Issue Application of Transcranial Direct Current Stimulation Based Methods in Neurological Diseases: New Advances and Perspectives)
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Abstract

Transcranial direct current stimulation (tDCS) is a promising non-invasive method to modulate brain excitability. The aim of this study was to better understand the cerebral blood flow (CBF) changes during and after repeated tDCS at the right dorsolateral prefrontal cortex (DLPFC) in healthy participants using pulsed continuous arterial spin labeling (pCASL). Elucidating CBF changes associated with repeated tDCS may shed light on the understanding of the mechanisms underlying the therapeutic effects of tDCS. tDCS was applied for three consecutive days for 20 min at 2 mA, and MRI scans were performed on day 1 and 3. During anodal tDCS, increased CBF was detected in the bilateral thalamus on day 1 and 3 (12% on day 1 and of 14% on day 3) and in the insula on day 1 (12%). After anodal tDCS on day 1, increased CBF was detected in the cerebellum and occipital lobe (11.8%), while both cathodal and sham tDCS were associated with increased CBF in the insula (11% and 10%, respectively). Moreover, anodal tDCS led to increased CBF in the lateral prefrontal cortex and midcingulate cortex in comparison to the sham. These findings suggest that tDCS can modulate the CBF and different tDCS modes may lead to different effects.
Keywords: dorsolateral prefrontal cortex (DLPFC); lateral prefrontal cortex (LPFC); pulsed continuous arterial spin labeling (pCASL); transcranial direct current stimulation (tDCS) dorsolateral prefrontal cortex (DLPFC); lateral prefrontal cortex (LPFC); pulsed continuous arterial spin labeling (pCASL); transcranial direct current stimulation (tDCS)

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MDPI and ACS Style

Sacca, V.; Maleki, N.; Wen, Y.; Hodges, S.; Kong, J. Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study. Brain Sci. 2023, 13, 395. https://doi.org/10.3390/brainsci13030395

AMA Style

Sacca V, Maleki N, Wen Y, Hodges S, Kong J. Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study. Brain Sciences. 2023; 13(3):395. https://doi.org/10.3390/brainsci13030395

Chicago/Turabian Style

Sacca, Valeria, Nasim Maleki, Ya Wen, Sierra Hodges, and Jian Kong. 2023. "Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study" Brain Sciences 13, no. 3: 395. https://doi.org/10.3390/brainsci13030395

APA Style

Sacca, V., Maleki, N., Wen, Y., Hodges, S., & Kong, J. (2023). Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study. Brain Sciences, 13(3), 395. https://doi.org/10.3390/brainsci13030395

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