Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus
Abstract
:1. Introduction
2. Materials and Methods
2.1. Slice and Cell Preparation
2.2. Electrophysiological Recordings
2.3. Multi-Photon Fluorescent Ca2+-Imaging in Astrocytes
2.4. Measurement of Extracellular ATP Concentration in Brain Tissue
2.5. Data Analysis
3. Results
3.1. Impact of mGluRs on Intracellular Ca2+-Signaling and Release of Gliotransmitters in Neocortical and Hippocampal Astrocytes
3.2. mGluR Receptors Induce the Release of ATP from Hippocampal and Neocortical Astrocytes
3.3. Impact of Impaired Gliotransmission on mGluR-Dependent LTD in Hippocampus and Neocortex
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lalo, U.; Pankratov, Y. Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus. Brain Sci. 2022, 12, 1718. https://doi.org/10.3390/brainsci12121718
Lalo U, Pankratov Y. Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus. Brain Sciences. 2022; 12(12):1718. https://doi.org/10.3390/brainsci12121718
Chicago/Turabian StyleLalo, Ulyana, and Yuriy Pankratov. 2022. "Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus" Brain Sciences 12, no. 12: 1718. https://doi.org/10.3390/brainsci12121718