Brain AVMs-Related microRNAs: Machine Learning Algorithm for Expression Profiles of Target Genes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources and Inclusion Criteria
2.2. Bioinformatic Analyses
3. Results
3.1. Literature Review and Data Extraction
3.2. MicroRNA Sequencing Analyses
3.2.1. miR-18a
3.2.2. miR-137 and miR-195*
3.2.3. Peripheral Blood miRNAs
3.3. Prediction of miRNA-Related Targets
4. Discussion
4.1. Experimental Strategies and Future Perspectives for bAVMs
4.2. Emerging miRNA-Based Therapies
4.3. Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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miRNA | Site | Status | Level of Gene Expression | Author, Year | Country | |
---|---|---|---|---|---|---|
High | Low | |||||
miR-18a | BECs | Downregulated | TSP-1, VEGF-A | Id-1, VEGF-D | Ferreira et al., 2014 [29] | USA |
TSP-1 | VEGF, PAI-1, BMP4, HIF-1α MMP2, MMP9, ADAM10 | Marín-Ramos et al., 2020 [30] | USA | |||
miR-137 | VSMCs | Downregulated | NA | VEGF, PI3K/Akt, MAPK/ERK, P38, NFkB | Huang et al., 2017 [31] | China |
miR-195* | ||||||
miR-7-5p | PB | Over-expressed | VEGF | NA | Chen et al., 2018 [32] | China |
miR-629-5p | ||||||
miR-199a-5p | ||||||
miR-200b-3p | ||||||
let-7b-5p | NA |
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Giotta Lucifero, A.; Luzzi, S. Brain AVMs-Related microRNAs: Machine Learning Algorithm for Expression Profiles of Target Genes. Brain Sci. 2022, 12, 1628. https://doi.org/10.3390/brainsci12121628
Giotta Lucifero A, Luzzi S. Brain AVMs-Related microRNAs: Machine Learning Algorithm for Expression Profiles of Target Genes. Brain Sciences. 2022; 12(12):1628. https://doi.org/10.3390/brainsci12121628
Chicago/Turabian StyleGiotta Lucifero, Alice, and Sabino Luzzi. 2022. "Brain AVMs-Related microRNAs: Machine Learning Algorithm for Expression Profiles of Target Genes" Brain Sciences 12, no. 12: 1628. https://doi.org/10.3390/brainsci12121628