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Article

Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment

1
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, 60020 Ancona, Italy
2
Department of Neurology, University of New Mexico, Albuquerque, NM 87131, USA
3
Neurological Service, SS Annunziata Hospital, Sulmona, 67039 L’Aquila, Italy
4
Departments of Neurology, Neurosurgery, and Radiology, University of Iowa, Iowa City, IA 52242, USA
5
Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
6
Clinical Department of Laboratory Services and Public Health—Legal Medicine Unit, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Giovanni Morone
Brain Sci. 2021, 11(9), 1164; https://doi.org/10.3390/brainsci11091164
Received: 4 August 2021 / Revised: 25 August 2021 / Accepted: 30 August 2021 / Published: 31 August 2021
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct plays a central role in stroke pathobiology that can influence the outcome of a recanalization procedure. The aim of this study was to evaluate the relationship between the systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. We retrospectively identified consecutive patients with ischemic stroke due to proximal arterial occlusion in the anterior circulation, who were treated with EVT and achieved near-complete or complete recanalization. Absolute neutrophil count (ANC), absolute monocyte count (AMC), and absolute lymphocyte count (ALC) were collected from admission blood work to calculate SIRI as ANC × AMC/ALC. The study outcome was futile recanalization, defined as poor functional status [modified Rankin scale (mRS) score ≥ 3] at 3 months despite complete or near-complete recanalization. A total of 184 patients were included. Futile recanalization was observed in 110 (59.8%) patients. Older patients (odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.04–1.10, p < 0.001), higher admission National Institutes of Health stroke scale score (OR = 1.10, 95% CI: 1.02–1.19, p = 0.013), and higher admission SIRI (OR = 1.08, 95% CI: 1.01–1.17, p = 0.028) increased the risk of the poor outcome at 3 months despite complete or near-complete recanalization. View Full-Text
Keywords: cerebrovascular disease; endovascular treatment; intravenous thrombolysis; inflammation; ischemic stroke; lymphocyte; mechanical thrombectomy; monocytes; neutrophil; recanalization; systemic inflammation response index cerebrovascular disease; endovascular treatment; intravenous thrombolysis; inflammation; ischemic stroke; lymphocyte; mechanical thrombectomy; monocytes; neutrophil; recanalization; systemic inflammation response index
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MDPI and ACS Style

Lattanzi, S.; Norata, D.; Divani, A.A.; Di Napoli, M.; Broggi, S.; Rocchi, C.; Ortega-Gutierrez, S.; Mansueto, G.; Silvestrini, M. Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment. Brain Sci. 2021, 11, 1164. https://doi.org/10.3390/brainsci11091164

AMA Style

Lattanzi S, Norata D, Divani AA, Di Napoli M, Broggi S, Rocchi C, Ortega-Gutierrez S, Mansueto G, Silvestrini M. Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment. Brain Sciences. 2021; 11(9):1164. https://doi.org/10.3390/brainsci11091164

Chicago/Turabian Style

Lattanzi, Simona, Davide Norata, Afshin A. Divani, Mario Di Napoli, Serena Broggi, Chiara Rocchi, Santiago Ortega-Gutierrez, Gelsomina Mansueto, and Mauro Silvestrini. 2021. "Systemic Inflammatory Response Index and Futile Recanalization in Patients with Ischemic Stroke Undergoing Endovascular Treatment" Brain Sciences 11, no. 9: 1164. https://doi.org/10.3390/brainsci11091164

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