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Cerebral Hemodynamics and Intracranial Compliance Impairment in Critically Ill COVID-19 Patients: A Pilot Study

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Division of Neurosurgery, Department of Neurology, Universidade de São Paulo, São Paulo 05403-000, Brazil
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Department of Intensive Care, Universitè Libre de Bruxelles, 1000 Brussels, Belgium
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Department of Intensive Care, Universidade de São Paulo, São Paulo 05403-000, Brazil
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Division of Critical Care Medicine and the Department of Anesthesiology, Université Laval, Québec City, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Hideki Hida
Brain Sci. 2021, 11(7), 874; https://doi.org/10.3390/brainsci11070874
Received: 15 June 2021 / Revised: 26 June 2021 / Accepted: 28 June 2021 / Published: 30 June 2021
Introduction: One of the possible mechanisms by which the new coronavirus (SARS-Cov2) could induce brain damage is the impairment of cerebrovascular hemodynamics (CVH) and intracranial compliance (ICC) due to the elevation of intracranial pressure (ICP). The main objective of this study was to assess the presence of CVH and ICC alterations in patients with COVID-19 and evaluate their association with short-term clinical outcomes. Methods: Fifty consecutive critically ill COVID-19 patients were studied with transcranial Doppler (TCD) and non-invasive monitoring of ICC. Subjects were included upon ICU admission; CVH was evaluated using mean flow velocities in the middle cerebral arteries (mCBFV), pulsatility index (PI), and estimated cerebral perfusion pressure (eCPP), while ICC was assessed by using the P2/P1 ratio of the non-invasive ICP curve. A CVH/ICC score was computed using all these variables. The primary composite outcome was unsuccessful in weaning from respiratory support or death on day 7 (defined as UO). Results: At the first assessment (n = 50), only the P2/P1 ratio (median 1.20 [IQRs 1.00–1.28] vs. 1.00 [0.88–1.16]; p = 0.03) and eICP (14 [11–25] vs. 11 [7–15] mmHg; p = 0.01) were significantly higher among patients with an unfavorable outcome (UO) than others. Patients with UO had a significantly higher CVH/ICC score (9 [8–12] vs. 6 [5–7]; p < 0.001) than those with a favorable outcome; the area under the receiver operating curve (AUROC) for CVH/ICC score to predict UO was 0.86 (95% CIs 0.75–0.97); a score > 8.5 had 63 (46–77)% sensitivity and 87 (62–97)% specificity to predict UO. For those patients undergoing a second assessment (n = 29), after a median of 11 (5–31) days, all measured variables were similar between the two time-points. No differences in the measured variables between ICU non-survivors (n = 30) and survivors were observed. Conclusions: ICC impairment and CVH disturbances are often present in COVID-19 severe illness and could accurately predict an early poor outcome. View Full-Text
Keywords: intracranial pressure; intracranial compliance; cerebrovascular resistance; cerebral perfusion pressure; COVID-19 intracranial pressure; intracranial compliance; cerebrovascular resistance; cerebral perfusion pressure; COVID-19
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MDPI and ACS Style

Brasil, S.; Taccone, F.S.; Wayhs, S.Y.; Tomazini, B.M.; Annoni, F.; Fonseca, S.; Bassi, E.; Lucena, B.; Nogueira, R.D.C.; De-Lima-Oliveira, M.; Bor-Seng-Shu, E.; Paiva, W.; Turgeon, A.F.; Jacobsen Teixeira, M.; Malbouisson, L.M.S. Cerebral Hemodynamics and Intracranial Compliance Impairment in Critically Ill COVID-19 Patients: A Pilot Study. Brain Sci. 2021, 11, 874. https://doi.org/10.3390/brainsci11070874

AMA Style

Brasil S, Taccone FS, Wayhs SY, Tomazini BM, Annoni F, Fonseca S, Bassi E, Lucena B, Nogueira RDC, De-Lima-Oliveira M, Bor-Seng-Shu E, Paiva W, Turgeon AF, Jacobsen Teixeira M, Malbouisson LMS. Cerebral Hemodynamics and Intracranial Compliance Impairment in Critically Ill COVID-19 Patients: A Pilot Study. Brain Sciences. 2021; 11(7):874. https://doi.org/10.3390/brainsci11070874

Chicago/Turabian Style

Brasil, Sérgio, Fabio Silvio Taccone, Sâmia Yasin Wayhs, Bruno Martins Tomazini, Filippo Annoni, Sérgio Fonseca, Estevão Bassi, Bruno Lucena, Ricardo De Carvalho Nogueira, Marcelo De-Lima-Oliveira, Edson Bor-Seng-Shu, Wellingson Paiva, Alexis Fournier Turgeon, Manoel Jacobsen Teixeira, and Luiz Marcelo Sá Malbouisson. 2021. "Cerebral Hemodynamics and Intracranial Compliance Impairment in Critically Ill COVID-19 Patients: A Pilot Study" Brain Sciences 11, no. 7: 874. https://doi.org/10.3390/brainsci11070874

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