Next Article in Journal / Special Issue
The Timecourse of Electrophysiological Brain–Heart Interaction in DoC Patients
Previous Article in Journal
Informal Caregiving in Amyotrophic Lateral Sclerosis (ALS): A High Caregiver Burden and Drastic Consequences on Caregivers’ Lives
Previous Article in Special Issue
A Recent Investigation on Detection and Classification of Epileptic Seizure Techniques Using EEG Signal
Article

Disruptions in Effective Connectivity within and between Default Mode Network and Anterior Forebrain Mesocircuit in Prolonged Disorders of Consciousness

1
Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham B15 2TT, UK
2
Trinity College Institute of Neuroscience, School of Psychology, Trinity College Dublin, D02 PN40 Dublin, Ireland
3
Brain and Mind Institute, Western University, London, ON N6A 5B7, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Rocco Salvatore Calabrò and Antonino Naro
Brain Sci. 2021, 11(6), 749; https://doi.org/10.3390/brainsci11060749
Received: 1 April 2021 / Revised: 25 May 2021 / Accepted: 30 May 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Advances in Disorders of Consciousness)
Recent research indicates prolonged disorders of consciousness (PDOC) result from structural and functional impairments to key cortical and subcortical networks, including the default mode network (DMN) and the anterior forebrain mesocircuit (AFM). However, the specific mechanisms which underpin such impairments remain unknown. It is known that disruptions in the striatal-pallidal pathway can result in the over inhibition of the thalamus and lack of excitation to the cortex that characterizes PDOC. Here, we used spectral dynamic causal modelling and parametric empirical Bayes on rs-fMRI data to assess whether DMN changes in PDOC are caused by disruptions in the AFM. PDOC patients displayed overall reduced coupling within the AFM, and specifically, decreased self-inhibition of the striatum, paired with reduced coupling from striatum to thalamus. This led to loss of inhibition from AFM to DMN, mostly driven by posterior areas including the precuneus and inferior parietal cortex. In turn, the DMN showed disruptions in self-inhibition of the precuneus and medial prefrontal cortex. Our results provide support for the anterior mesocircuit model at the subcortical level but highlight an inhibitory role for the AFM over the DMN, which is disrupted in PDOC. View Full-Text
Keywords: disorders of consciousness; default mode network; anterior forebrain mesocircuit; dynamic causal modelling; effective connectivity; fMRI; parametric empirical Bayes; vegetative state; minimally conscious state; coma recovery scale-revised disorders of consciousness; default mode network; anterior forebrain mesocircuit; dynamic causal modelling; effective connectivity; fMRI; parametric empirical Bayes; vegetative state; minimally conscious state; coma recovery scale-revised
Show Figures

Figure 1

MDPI and ACS Style

Coulborn, S.; Taylor, C.; Naci, L.; Owen, A.M.; Fernández-Espejo, D. Disruptions in Effective Connectivity within and between Default Mode Network and Anterior Forebrain Mesocircuit in Prolonged Disorders of Consciousness. Brain Sci. 2021, 11, 749. https://doi.org/10.3390/brainsci11060749

AMA Style

Coulborn S, Taylor C, Naci L, Owen AM, Fernández-Espejo D. Disruptions in Effective Connectivity within and between Default Mode Network and Anterior Forebrain Mesocircuit in Prolonged Disorders of Consciousness. Brain Sciences. 2021; 11(6):749. https://doi.org/10.3390/brainsci11060749

Chicago/Turabian Style

Coulborn, Sean, Chris Taylor, Lorina Naci, Adrian M. Owen, and Davinia Fernández-Espejo. 2021. "Disruptions in Effective Connectivity within and between Default Mode Network and Anterior Forebrain Mesocircuit in Prolonged Disorders of Consciousness" Brain Sciences 11, no. 6: 749. https://doi.org/10.3390/brainsci11060749

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop