Next Article in Journal
Association between Functional Brain Network Metrics and Surgeon Performance and Distraction in the Operating Room
Previous Article in Journal
Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas
Previous Article in Special Issue
Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome
Open AccessReview

Frontal Transcranial Direct Current Stimulation as a Potential Treatment of Parkinson’s Disease-Related Fatigue

by 1,2
1
Department of Neurology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany
2
Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany
Academic Editors: Ulrich Palm, Moussa Antoine Chalah and Samar S. Ayache
Brain Sci. 2021, 11(4), 467; https://doi.org/10.3390/brainsci11040467
Received: 26 February 2021 / Revised: 22 March 2021 / Accepted: 30 March 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Brain Stimulation and Neuroplasticity)
In contrast to motor symptoms, non-motor symptoms in Parkinson’s disease (PD) are often poorly recognized and inadequately treated. Fatigue is one of the most common non-motor symptoms in PD and affects a broad range of everyday activities, causes disability, and substantially reduces the quality of life. It occurs at every stage of PD, and once present, it often persists and worsens over time. PD patients attending the 2013 World Parkinson Congress voted fatigue as the leading symptom in need of further research. However, despite its clinical significance, little progress has been made in understanding the causes of Parkinson’s disease-related fatigue (PDRF) and developing effective treatment options, which argues strongly for a greater effort. Transcranial direct current stimulation (tDCS) is a technique to non-invasively modulate cortical excitability by delivering low electrical currents to the cerebral cortex. In the past, it has been consistently evidenced that tDCS has the ability to induce neuromodulatory changes in the motor, sensory, and cognitive domains. Importantly, recent data present tDCS over the frontal cortex as an effective therapeutic option to treat fatigue in patients suffering from multiple sclerosis (MS). The current opinion paper reviews recent data on PDRF and the application of tDCS for the treatment of fatigue in neuropsychiatric disorders to further develop an idea of using frontal anodal tDCS as a potential therapeutic strategy to alleviate one of the most common and severe non-motor symptoms of PD. View Full-Text
Keywords: fatigue; Parkinson’s disease (PD); tDCS fatigue; Parkinson’s disease (PD); tDCS
MDPI and ACS Style

Zaehle, T. Frontal Transcranial Direct Current Stimulation as a Potential Treatment of Parkinson’s Disease-Related Fatigue. Brain Sci. 2021, 11, 467. https://doi.org/10.3390/brainsci11040467

AMA Style

Zaehle T. Frontal Transcranial Direct Current Stimulation as a Potential Treatment of Parkinson’s Disease-Related Fatigue. Brain Sciences. 2021; 11(4):467. https://doi.org/10.3390/brainsci11040467

Chicago/Turabian Style

Zaehle, Tino. 2021. "Frontal Transcranial Direct Current Stimulation as a Potential Treatment of Parkinson’s Disease-Related Fatigue" Brain Sci. 11, no. 4: 467. https://doi.org/10.3390/brainsci11040467

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop