The Dying Forward Hypothesis of ALS: Tracing Its History
Round 1
Reviewer 1 Report
In this review article, the authors historically summarized the dying forward hypothesis of ALS. There are still some hypotheses about ALS. This article focused on one of the major hypotheses and reviewed its history. The history is briefly and comprehensively summarized in this article. Thus, I recommend publishing this paper in this journal.
Reviewer 2 Report
The manuscript discusses the pathophysiology mechanisms of ALS through a historic perspective, including different theories and models to understand the course of the disease. This is a very interesting manuscript that brings an important perspective on ALS pathophysiology based on current evidence that supports the author`s theory. I would like to congratulate the author for the manuscript.
Some minor comments:
Line 44: first time mentioned the acronym MND, please describe.
Line 147: same as above for CST
Line 171: PTN was already mentioned on line 103, you can use the acronym here.
Line 170-178: this is just a format issue since the paragraph is curt in two.
