Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Drugs and Chemicals
2.2. Animals
2.3. Experimental Design
2.4. Behavioral Assessment Using the Radial Arm Maze (RAM)
2.5. Collection of Brain Homogenate
2.6. Determination of Cytokines and Cyclooxygenase levels
2.7. Determination of Mitochondrial Respiratory Chain Complexes (MRCC)
2.8. Statistical Analysis
3. Results
3.1. CLO Improved Memory Functions in LPS-Treated Mice Using the RAM
3.2. CLO Reduced Pro-Inflammatory Cytokine Levels in LPS-Treated Mice
3.3. CLO Improved Anti-Inflammatory Cytokine Levels in LPS-Treated Mice
3.4. CLO Reduced Cyclooxygenase-2 (COX-2) Activities in LPS-Treated Mice
3.5. CLO Improved Mitochondrial Respiratory Chain Complexes (MRCC) Activities in LPS-Treated Mice
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Mani, V.; Arfeen, M.; Ali, H.M.; Abdel-Moneim, A.-M.H.; Aldubayan, M.; Alhowail, A. Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice. Brain Sci. 2021, 11, 1617. https://doi.org/10.3390/brainsci11121617
Mani V, Arfeen M, Ali HM, Abdel-Moneim A-MH, Aldubayan M, Alhowail A. Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice. Brain Sciences. 2021; 11(12):1617. https://doi.org/10.3390/brainsci11121617
Chicago/Turabian StyleMani, Vasudevan, Minhajul Arfeen, Hussein M. Ali, Abdel-Moneim Hafez Abdel-Moneim, Maha Aldubayan, and Ahmad Alhowail. 2021. "Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice" Brain Sciences 11, no. 12: 1617. https://doi.org/10.3390/brainsci11121617
APA StyleMani, V., Arfeen, M., Ali, H. M., Abdel-Moneim, A.-M. H., Aldubayan, M., & Alhowail, A. (2021). Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice. Brain Sciences, 11(12), 1617. https://doi.org/10.3390/brainsci11121617