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Study Protocol

The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol

1
Guangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China
2
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
3
Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518132, China
4
Department of Rehabilitation Medicine, The Fifth People’s Hospital of Foshan, Foshan 528211, China
5
Department of Traditional Chinese Medicine, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, China
*
Authors to whom correspondence should be addressed.
Equal contribution.
Academic Editors: Shapour Jaberzadeh, Jonathan Marsden and Konstantin V. Slavin
Brain Sci. 2021, 11(11), 1495; https://doi.org/10.3390/brainsci11111495
Received: 4 August 2021 / Revised: 5 November 2021 / Accepted: 8 November 2021 / Published: 12 November 2021
Background: The efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery may also benefit from interlimb-coordinated training since most everyday activities require the coordinated use of both hands to complete a task. This study investigates the efficacy of interlimb-coordinated training on gait and upper limb functional recovery over a short-medium term period. Methods: A total of 226 acute stroke patients will be recruited from four centres over four years. Patients will be randomly allocated to either conventional therapy or conventional therapy plus interlimb-coordinated training. Outcomes will be recorded at baseline, after 2 weeks of intervention, and at 3- and 6-months post-intervention. Gait speed is the primary outcome measure. Secondary outcome measures include Fugl–Meyer Assessment of Motor Recovery, Berg Balance Scale, Timed Up and Go test, Action Research Arm Test, electroencephalography, and magnetic resonance imaging. Conclusion: The results of this trial will provide an in-depth understanding of the efficacy of early interlimb-coordinated intervention on gait and upper functional rehabilitation and how it may relate to the neural plasticity process. View Full-Text
Keywords: arm cycling; interlimb coordinated; limb linkage; gait; stroke; EEG; MRI arm cycling; interlimb coordinated; limb linkage; gait; stroke; EEG; MRI
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MDPI and ACS Style

Lo, W.-L.A.; Chen, D.; Zhao, J.; Leng, Y.; Bian, R.; Huang, W.; Liang, Y.; Mao, Y.-R.; Huang, D.-F. The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol. Brain Sci. 2021, 11, 1495. https://doi.org/10.3390/brainsci11111495

AMA Style

Lo W-LA, Chen D, Zhao J, Leng Y, Bian R, Huang W, Liang Y, Mao Y-R, Huang D-F. The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol. Brain Sciences. 2021; 11(11):1495. https://doi.org/10.3390/brainsci11111495

Chicago/Turabian Style

Lo, Wai-Leung Ambrose, Dandan Chen, Jiangli Zhao, Yan Leng, Ruihao Bian, Wenzhu Huang, Yahui Liang, Yu-Rong Mao, and Dong-Feng Huang. 2021. "The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol" Brain Sciences 11, no. 11: 1495. https://doi.org/10.3390/brainsci11111495

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