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Open AccessArticle

Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome

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Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
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Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
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Division of Child Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Departments of Pediatrics, Rush University Medical Center, Chicago, IL 60612, USA
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Departments of Pediatrics, Neurological Sciences, Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA
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Developmental Pediatrics, Children’s Hospital Colorado, Aurora, CO 80045, USA
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Division of Developmental Pediatrics, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(4), 213; https://doi.org/10.3390/brainsci10040213
Received: 29 February 2020 / Revised: 31 March 2020 / Accepted: 1 April 2020 / Published: 4 April 2020
(This article belongs to the Special Issue Update on the Treatment of Fragile X Syndrome)
Health-related quality of life (HRQoL) is a multidimensional concept involving physical, psychological, social, and cognitive aspects of life. Individuals with Fragile X syndrome (FXS) experience a life-long disorder that impacts the HRQoL of the affected individual and their family. Thus, HRQoL may be an important outcome measure following intervention. However, it is yet not known whether HRQoL concerns relate to observed impairments in FXS. In the present study, we examined the nature and degree of association between HRQoL and established measures of functioning in FXS using the Parent Report for Children version of the PedsQL 4.0 Generic Core Scales and Cognitive Functioning Scale. We observed significant relationships between HRQoL a nd measures of adaptive behavior, maladaptive behaviors, and social functioning. The present study has implications for treatment outcomes for clinical trials in FXS. View Full-Text
Keywords: fragile X syndrome; health-related quality of life; quality of life; adaptive behavior fragile X syndrome; health-related quality of life; quality of life; adaptive behavior
MDPI and ACS Style

Coffman, M.C.; Shaffer, R.C.; Schmitt, L.M.; Dominick, K.C.; Pedapati, E.; Wang, A.; Berry-Kravis, E.; Tartaglia, N.; Erickson, C.A. Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome. Brain Sci. 2020, 10, 213.

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