Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Blood Glucose Measurement
2.3. SDS-PAGE and Western Blotting Analysis
2.4. Electrophysiological Recording from Neurons and Astrocytes in Brain Slices
2.4.1. Selection and Recording from Astrocytes
2.4.2. Recording from Pyramidal Neurons
Statistical Methodology
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Méndez-González, M.P.; Rivera-Aponte, D.E.; Benedikt, J.; Maldonado-Martínez, G.; Tejeda-Bayron, F.; Skatchkov, S.N.; Eaton, M.J. Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice. Brain Sci. 2020, 10, 72. https://doi.org/10.3390/brainsci10020072
Méndez-González MP, Rivera-Aponte DE, Benedikt J, Maldonado-Martínez G, Tejeda-Bayron F, Skatchkov SN, Eaton MJ. Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice. Brain Sciences. 2020; 10(2):72. https://doi.org/10.3390/brainsci10020072
Chicago/Turabian StyleMéndez-González, Miguel P., David E. Rivera-Aponte, Jan Benedikt, Geronimo Maldonado-Martínez, Flavia Tejeda-Bayron, Serguei N. Skatchkov, and Misty J. Eaton. 2020. "Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice" Brain Sciences 10, no. 2: 72. https://doi.org/10.3390/brainsci10020072
APA StyleMéndez-González, M. P., Rivera-Aponte, D. E., Benedikt, J., Maldonado-Martínez, G., Tejeda-Bayron, F., Skatchkov, S. N., & Eaton, M. J. (2020). Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice. Brain Sciences, 10(2), 72. https://doi.org/10.3390/brainsci10020072