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Article

Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis

1
Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
2
Yonsei University College of Medicine, Seoul 03722, Korea
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Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA
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College of Medicine, Gyeongsang National University, Jinju 52727, Korea
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Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Korea
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Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea
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Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do 17035, Korea
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Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
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Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AB, UK
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Mental Health Networking Biomedical Research Centre (CIBERSAM), 08036 Barcelona, Spain
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Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, 11330 Stockholm, Sweden
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Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
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Department of Pediatrics, Luton & Dunstable University Hospital NHS Foundation Trust, Luton LU4ODZ, UK
14
CESP, Inserm UMR1178, Department of Psychiatry, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, 94275 Le Kremlin Bicêtre, France
15
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, CIBERSAM, 08830 Barcelona, Spain
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ICREA, Pg. Lluis Companys 23, 08010 Barcelona, Spain
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Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, 28029 Madrid, Spain
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Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK
19
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK
20
Department of Neurosciences, University of Padua, 90133 Padua, Italy
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Neurosciences Center, University of Padua, 90133 Padua, Italy
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Department of Psychiatry, University of Toledo Medical Center, Toledo, OH 43614, USA
23
Department of Internal Medicine IV, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria
24
Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, SE-581 85 Linköping, Sweden
25
Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of the Parnaiba Delta, Parnaiba 64202-020, Brazil
26
Department of Basic Sciences, Medicine Faculty of Tunis, Tunis El Manar University, 15 Rue Djebel Lakdar, Tunis 1007, Tunisia
27
University Hospital, University of São Paulo, São Paulo CEP 05508-000, Brazil
28
Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo CEP 01246-903, Brazil
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Laboratory of Neuroscience and National Institute of Biomarkers in Neuropsychiatry, Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo CEP 01246-903, Brazil
30
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 80336 Munich, Germany
31
Centre for Addiction & Mental Health, Toronto, ON M6J 1H4, Canada
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Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada
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Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy
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The Stockholm Center for Health and Social Change (SCOHOST), Södertörn University, 141 89 Huddinge, Sweden
35
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo 187-8553, Japan
36
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK
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Department of Psychology, University of Greenwich, London SE10 9LS, UK
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OASIS Service, South London and Maudsley NHS Foundation Trust, London SE8 5HA, UK
39
Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Brain Sci. 2020, 10(10), 692; https://doi.org/10.3390/brainsci10100692
Received: 19 August 2020 / Revised: 13 September 2020 / Accepted: 14 September 2020 / Published: 30 September 2020
(This article belongs to the Special Issue Advances in Autism Research)
This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood. View Full-Text
Keywords: autism spectrum disorder; false positive report probability (FPRP); Bayesian false-discovery probability (BFDP); meta-analysis; Genome-Wide Association Studies (GWAS) autism spectrum disorder; false positive report probability (FPRP); Bayesian false-discovery probability (BFDP); meta-analysis; Genome-Wide Association Studies (GWAS)
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Figure 1

MDPI and ACS Style

Lee, J.; Son, M.J.; Son, C.Y.; Jeong, G.H.; Lee, K.H.; Lee, K.S.; Ko, Y.; Kim, J.Y.; Lee, J.Y.; Radua, J.; Eisenhut, M.; Gressier, F.; Koyanagi, A.; Stubbs, B.; Solmi, M.; Rais, T.B.; Kronbichler, A.; Dragioti, E.; Vasconcelos, D.F.P.; Silva, F.R.P.d.; Tizaoui, K.; Brunoni, A.R.; Carvalho, A.F.; Cargnin, S.; Terrazzino, S.; Stickley, A.; Smith, L.; Thompson, T.; Shin, J.I.; Fusar-Poli, P. Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis. Brain Sci. 2020, 10, 692. https://doi.org/10.3390/brainsci10100692

AMA Style

Lee J, Son MJ, Son CY, Jeong GH, Lee KH, Lee KS, Ko Y, Kim JY, Lee JY, Radua J, Eisenhut M, Gressier F, Koyanagi A, Stubbs B, Solmi M, Rais TB, Kronbichler A, Dragioti E, Vasconcelos DFP, Silva FRPd, Tizaoui K, Brunoni AR, Carvalho AF, Cargnin S, Terrazzino S, Stickley A, Smith L, Thompson T, Shin JI, Fusar-Poli P. Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis. Brain Sciences. 2020; 10(10):692. https://doi.org/10.3390/brainsci10100692

Chicago/Turabian Style

Lee, Jinhee, Min J. Son, Chei Y. Son, Gwang H. Jeong, Keum H. Lee, Kwang S. Lee, Younhee Ko, Jong Y. Kim, Jun Y. Lee, Joaquim Radua, Michael Eisenhut, Florence Gressier, Ai Koyanagi, Brendon Stubbs, Marco Solmi, Theodor B. Rais, Andreas Kronbichler, Elena Dragioti, Daniel F.P. Vasconcelos, Felipe R.P.d. Silva, Kalthoum Tizaoui, André R. Brunoni, Andre F. Carvalho, Sarah Cargnin, Salvatore Terrazzino, Andrew Stickley, Lee Smith, Trevor Thompson, Jae I. Shin, and Paolo Fusar-Poli. 2020. "Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis" Brain Sciences 10, no. 10: 692. https://doi.org/10.3390/brainsci10100692

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