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Open AccessArticle

Potential of Novel Bacterial Cellulose Dressings Chemisorbed with Antiseptics for the Treatment of Oral Biofilm Infections

1
Nutrikon, KCZ Surgical Ward, 47-300 Krapkowice, Poland
2
Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, 50-556 Wrocław, Poland
3
Department of Clinical Chemistry, Wroclaw Medical University, 50-556 Wroclaw, Poland
4
Faculty of Biotechnology and Animal Husbandry, Department of Immunology, Microbiology and Physiological Chemistry, West Pomeranian University of Technology in Szczecin, 70-311 Szczecin, Poland
5
Center for Biofilms and Infection and Immunity Laboratory, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, CA 90089, USA
6
Center for Advanced Manufacturing Technologies (CAMT/FPC), Faculty of Mechanical Engineering, Wroclaw University of Technology, 50-556 Wroclaw, Poland
7
Laboratory of Microbiology, Łukasiewicz Research Network–PORT Polish Center for Technology Development, 54-066 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(24), 5321; https://doi.org/10.3390/app9245321
Received: 29 October 2019 / Revised: 2 December 2019 / Accepted: 3 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Bacterial Cellulose Biomaterials)
Infections of the oral cavity are caused by multicellular communities of microbes, referred to as biofilms. Due to the high tolerance of biofilms to antibiotics and specific conditions within the oral cavity, there is an ongoing search for carriers that are able to deliver high local concentrations of potent antimicrobials that can eradicate pathogenic biofilms. Bacterial cellulose, owing to its high flexibility, absorbance, and release potential, meets these demands. In this work we chemisorbed bacterial cellulose with antiseptics containing povidone-iodine or polihexanide and analyzed their ability to eradicate in vitro biofilms formed by oral pathogens, such as Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Pseudomonas aeruginosa. In tests performed by means of standard laboratory methods and with a long contact time (24 h), all antiseptics released from the cellulose dressings displayed a very high antibiofilm efficacy. On the other hand, when conditions imitating the oral cavity were used and cellulose dressings were applied for a 0.5–1 h contact time, the antiseptics released from the dressings displayed lower, though still acceptable, activity. Our findings indicate that besides species-specific resistance to particular antiseptic agents, environmental and experimental settings play an essential role in outcomes. Finally, in a proof-of-concept experiment performed in an oral cavity typodont model, we demonstrated the high flexibility and adhesiveness of antiseptic-containing cellulose dressings. Our novel findings, if developed in further studies, may lead to the introduction of new types of dressings that are able to efficiently deal with biofilm infections of the oral cavity. View Full-Text
Keywords: antiseptic; bacterial cellulose; biofilm; dressing; oral cavity antiseptic; bacterial cellulose; biofilm; dressing; oral cavity
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MDPI and ACS Style

Krasowski, G.; Wicher-Dudek, R.; Paleczny, J.; Bil-Lula, I.; Fijałkowski, K.; Sedghizadeh, P.P.; Szymczyk, P.; Dudek, B.; Bartoszewicz, M.; Junka, A. Potential of Novel Bacterial Cellulose Dressings Chemisorbed with Antiseptics for the Treatment of Oral Biofilm Infections. Appl. Sci. 2019, 9, 5321. https://doi.org/10.3390/app9245321

AMA Style

Krasowski G, Wicher-Dudek R, Paleczny J, Bil-Lula I, Fijałkowski K, Sedghizadeh PP, Szymczyk P, Dudek B, Bartoszewicz M, Junka A. Potential of Novel Bacterial Cellulose Dressings Chemisorbed with Antiseptics for the Treatment of Oral Biofilm Infections. Applied Sciences. 2019; 9(24):5321. https://doi.org/10.3390/app9245321

Chicago/Turabian Style

Krasowski, Grzegorz; Wicher-Dudek, Ruth; Paleczny, Justyna; Bil-Lula, Iwona; Fijałkowski, Karol; Sedghizadeh, Parish P.; Szymczyk, Patrycja; Dudek, Bartłomiej; Bartoszewicz, Marzenna; Junka, Adam. 2019. "Potential of Novel Bacterial Cellulose Dressings Chemisorbed with Antiseptics for the Treatment of Oral Biofilm Infections" Appl. Sci. 9, no. 24: 5321. https://doi.org/10.3390/app9245321

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