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Open AccessArticle

Toward Development of a Vocal Fold Contact Pressure Probe: Bench-Top Validation of a Dual-Sensor Probe Using Excised Human Larynx Models

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Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA
2
Department of Surgery, Massachusetts General Hospital–Harvard Medical School, Boston, MA 02114, USA
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MGH Institute of Health Professions, Boston, MA 02129, USA
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Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA
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Department of Electronic Engineering, Universidad Técnica Federico Santa María, Valparaíso 2390123, Chile
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Department of Mechanical & Aeronautical Engineering, Clarkson University, Potsdam, NY 13699, USA
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Department of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(20), 4360; https://doi.org/10.3390/app9204360
Received: 19 September 2019 / Revised: 9 October 2019 / Accepted: 12 October 2019 / Published: 16 October 2019
(This article belongs to the Special Issue Computational Methods and Engineering Solutions to Voice)
A critical element in understanding voice production mechanisms is the characterization of vocal fold collision, which is widely considered a primary etiological factor in the development of common phonotraumatic lesions such as nodules and polyps. This paper describes the development of a transoral, dual-sensor intraglottal/subglottal pressure probe for the simultaneous measurement of vocal fold collision and subglottal pressures during phonation using two miniature sensors positioned 7.6 mm apart at the distal end of a rigid cannula. Proof-of-concept testing was performed using excised whole-mount and hemilarynx human tissue aerodynamically driven into self-sustained oscillation, with systematic variation of the superior–inferior positioning of the vocal fold collision sensor. In the hemilarynx experiment, signals from the pressure sensors were synchronized with an acoustic microphone, a tracheal-surface accelerometer, and two high-speed video cameras recording at 4000 frames per second for top–down and en face imaging of the superior and medial vocal fold surfaces, respectively. As expected, the intraglottal pressure signal exhibited an impulse-like peak when vocal fold contact occurred, followed by a broader peak associated with intraglottal pressure build-up during the de-contacting phase. As subglottal pressure was increased, the peak amplitude of the collision pressure increased and typically reached a value below that of the average subglottal pressure. Results provide important baseline vocal fold collision pressure data with which computational models of voice production can be developed and in vivo measurements can be referenced. View Full-Text
Keywords: subglottal pressure; intraglottal pressure; vocal fold collision; hemilarynx; excised larynx subglottal pressure; intraglottal pressure; vocal fold collision; hemilarynx; excised larynx
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Mehta, D.D.; Kobler, J.B.; Zeitels, S.M.; Zañartu, M.; Erath, B.D.; Motie-Shirazi, M.; Peterson, S.D.; Petrillo, R.H.; Hillman, R.E. Toward Development of a Vocal Fold Contact Pressure Probe: Bench-Top Validation of a Dual-Sensor Probe Using Excised Human Larynx Models. Appl. Sci. 2019, 9, 4360.

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