With respect to heavy carrying tasks and uneven road surface in open pit mine, the mechanical performances of electric wheel dump truck frame regarded as the main bearing component are extremely important for its safe operation. For the problem of insufficient strength and stiffness, an interval multi-objectives optimization design method based on blind number theory is presented in this paper, taking into account uncertain factors caused by manufacturing process. The allowable interval strength of welding material and permissible interval bending and torsional stiffness are obtained by means of experiments and simulations, using the blind number theory. Based on Latin hypercube sampling technique, the strength and stiffness of frame under different conditions is estimated. It shows that in the case of braking interference between interval strength and interval dynamic stress appears. Strength and stiffness are considered as optimization objectives, while the thicknesses of top longitudinal beam, stiffener, lateral longitudinal beam and hanging ear in the frame are deeded as design variables, and Young’s modulus and Poisson’s ratio are taken as uncertain variables. The optimized results show that the stress and deformation of the frame due to dynamic loading decreased. This result enables to formulate the following sentence: the mechanical performance of frame is improved.
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