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Open AccessArticle

Electrowetting on Dielectric (EWOD) Device with Dimple Structures for Highly Accurate Droplet Manipulation

1
Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan
2
Research Center for Ubiquitous MEMS and Micro Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki 305-8564, Japan
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(12), 2406; https://doi.org/10.3390/app9122406
Received: 26 April 2019 / Revised: 6 June 2019 / Accepted: 7 June 2019 / Published: 13 June 2019
(This article belongs to the Special Issue Microfluidics in Biomedical Engineering)
Digital microfluidics based on electrowetting on dielectric (EWOD) devices has potential as a fundamental technology for the accurate preparation of dangerous reagents, the high-speed dispensing of rapidly deteriorating reagents, and the fine adjustment of expensive reagents, such as the preparation of for positron emission tomography (PET). To allow single substrate type EWODs to be practically used in an automatic operation system, we developed a dimple structure as a key technique for a highly accurate droplet manipulation method. The three-dimensional shape of the dimple structure is embossed onto a disposable thin sheet. In this study, we confirmed that the dimple structure can suppress unintended droplet motion caused by unidentified factors. In addition, the stability of the droplets on the dimple structures was evaluated using a sliding experiment. On a flat substrate, the success rate of a droplet motion was lower than 70.8%, but on the dimple structure, the droplets were able to be moved along the dimple structures correctly without unintended motion caused by several environmental conditions. These results indicated that the dimple structure increased the controllability of the droplets. Hence, the dimple structure will contribute to the practical application of digital microfluidics based on single substrate type EWODs. View Full-Text
Keywords: digital microfluidics; electrowetting on dielectric; EWOD; dimple structure; sliding method; droplet digital microfluidics; electrowetting on dielectric; EWOD; dimple structure; sliding method; droplet
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MDPI and ACS Style

Mogi, K.; Adachi, S.; Takada, N.; Inoue, T.; Natsume, T. Electrowetting on Dielectric (EWOD) Device with Dimple Structures for Highly Accurate Droplet Manipulation. Appl. Sci. 2019, 9, 2406.

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