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Review

Microfluidic Technology for Cell Manipulation

by 1,* and 2,*
1
Department of Mechanical Engineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea
2
Department of Mechanical Engineering, Hanyang University, 55 Hanyangdaehak-ro, Sangrok-gu, Ansan, Gyeonggi-do 15588, Korea
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2018, 8(6), 992; https://doi.org/10.3390/app8060992
Received: 26 April 2018 / Revised: 8 June 2018 / Accepted: 14 June 2018 / Published: 17 June 2018
(This article belongs to the Special Issue Microfluidics in Biology and Medicine)
Microfluidic techniques for cell manipulation have been constantly developed and integrated into small chips for high-performance bioassays. However, the drawbacks of each of the techniques often hindered their further advancement and their wide use in biotechnology. To overcome this difficulty, an examination and understanding of various aspects of the developed manipulation techniques are required. In this review, we provide the details of primary microfluidic techniques that have received much attention for bioassays. First, we introduce the manipulation techniques using a sole driving source, i.e., dielectrophoresis, electrophoresis, optical tweezers, magnetophoresis, and acoustophoresis. Next, we present rapid electrokinetic patterning, a hybrid opto-electric manipulation technique developed recently. It is introduced in detail along with the underlying physical principle, operating environment, and current challenges. This paper will offer readers the opportunity to improve existing manipulation techniques, suggest new manipulation techniques, and find new applications in biotechnology. View Full-Text
Keywords: cell manipulation; dielectrophoresis; electrophoresis; optical tweezers; magnetophoresis; acoustophoresis; rapid electrokinetic patterning cell manipulation; dielectrophoresis; electrophoresis; optical tweezers; magnetophoresis; acoustophoresis; rapid electrokinetic patterning
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MDPI and ACS Style

Kwon, J.-S.; Oh, J.H. Microfluidic Technology for Cell Manipulation. Appl. Sci. 2018, 8, 992. https://doi.org/10.3390/app8060992

AMA Style

Kwon J-S, Oh JH. Microfluidic Technology for Cell Manipulation. Applied Sciences. 2018; 8(6):992. https://doi.org/10.3390/app8060992

Chicago/Turabian Style

Kwon, Jae-Sung, and Je H. Oh. 2018. "Microfluidic Technology for Cell Manipulation" Applied Sciences 8, no. 6: 992. https://doi.org/10.3390/app8060992

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