Prostate Clinical Outlook Visualization System for Patients and Clinicians Considering Cyberknife Treatment—A Personalized Approach
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. The Prostate Clinical Outlook Visualization System
3.1.1. Likely Outcome Visualization (Patient Specific Data vs. Reference Cyberknife Treated Patient Data)
3.1.2. Disease Free Survival Likely Outcome Visualization
3.1.3. Risk Free Profile Visualization
3.2. Longitudinal Trend for Visualization (Patient Specific Data vs. Reference SBRT Treated Patient Data)
3.2.1. BCR Free Survival Curve Visualization
3.2.2. Quality of Life Trends (Rectal, Urinary, and Sexual)
Rectal Quality of Life Trends
Urinary Quality of Life Trends
Sexual Quality of Life Trends
3.3. PSA Trends Visualization for Physician
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Ethical Approval
Appendix A. EPIC 26 Instrument
No Problem | Very Small Problem | Small Problem | Moderate Problem | Big Problem | |
a. Dripping or leaking urine | 0 | 1 | 2 | 3 | 4 |
b. Pain or burning on urination | 0 | 1 | 2 | 3 | 4 |
c. Bleeding with urination | 0 | 1 | 2 | 3 | 4 |
d. Weak urine stream or incomplete emptying | 0 | 1 | 2 | 3 | 4 |
e. Need to urinate frequently during the day | 0 | 1 | 2 | 3 | 4 |
No Problem | Very Small Problem | Small Problem | Moderate Problem | Big Problem | |
a. Urgency to have a bowel movement | 0 | 1 | 2 | 3 | 4 |
b. Increased frequency of bowel movements | 0 | 1 | 2 | 3 | 4 |
c. Losing control of your stools | 0 | 1 | 2 | 3 | 4 |
d. Bloody stools | 0 | 1 | 2 | 3 | 4 |
e. Abdominal/ Pelvic/Rectal pain | 0 | 1 | 2 | 3 | 4 |
Very Poor to None | Poor | Fair | Good | Very Good | |
Your ability to have an erection? | 1 | 2 | 3 | 4 | 5 |
Your ability to reach orgasm (climax)? | 1 | 2 | 3 | 4 | 5 |
No Problem | Very Small Problem | Small Problem | Moderate Problem | Big Problem | |
a. Hot flashes | 0 | 1 | 2 | 3 | 4 |
b. Breast tenderness/enlargement | 0 | 1 | 2 | 3 | 4 |
c. Feeling depressed | 0 | 1 | 2 | 3 | 4 |
d. Lack of energy | 0 | 1 | 2 | 3 | 4 |
e. Change in body weight | 0 | 1 | 2 | 3 | 4 |
Appendix B. Quality of Life Trends (Rectal, Urinary, and Sexual)
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Category | Frequency | Percent | |
---|---|---|---|
Age at diagnosis (Mean, Range) | Under 59 | 48 | 8.3 |
60–69 | 230 | 39.7 | |
70–79 | 247 | 42.6 | |
Over 80 | 55 | 9.5 | |
69.63 (44–94) | |||
T-stage | T1(T1b, T1c) | 396 | 68.3 |
T2a | 92 | 15.9 | |
T2b | 64 | 11 | |
T2c+T3 | 28 | 4.8 | |
Gleason score | Low | 236 | 40.7 |
Intermediate-a (3 + 4) | 210 | 36.2 | |
Intermediate-b (4 + 3) | 90 | 15.5 | |
High | 44 | 7.6 | |
Pre-treatment prostate specific antigen (PSA) | ≤10.0 ng/mL | 446 | 76.9 |
>10.0 and ≤20.0 ng/mL | 105 | 18.1 | |
>20.0 ng/mL | 29 | 5.0 | |
Race | Asian | 21 | 3.6 |
Black | 226 | 39 | |
Hispanic | 13 | 2.2 | |
White | 308 | 53.1 | |
Other | 12 | 2.1 | |
BCR | Patients with BCR | 17 | 2.9 |
Patients with non-BCR | 563 | 97.1 | |
Total | 580 | 100 |
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Share and Cite
Park, J.; Rho, M.J.; Dritschilo, A.; Choi, I.Y.; Mun, S.K. Prostate Clinical Outlook Visualization System for Patients and Clinicians Considering Cyberknife Treatment—A Personalized Approach. Appl. Sci. 2018, 8, 471. https://doi.org/10.3390/app8030471
Park J, Rho MJ, Dritschilo A, Choi IY, Mun SK. Prostate Clinical Outlook Visualization System for Patients and Clinicians Considering Cyberknife Treatment—A Personalized Approach. Applied Sciences. 2018; 8(3):471. https://doi.org/10.3390/app8030471
Chicago/Turabian StylePark, Jihwan, Mi Jung Rho, Anatoly Dritschilo, In Young Choi, and Seong K. Mun. 2018. "Prostate Clinical Outlook Visualization System for Patients and Clinicians Considering Cyberknife Treatment—A Personalized Approach" Applied Sciences 8, no. 3: 471. https://doi.org/10.3390/app8030471
APA StylePark, J., Rho, M. J., Dritschilo, A., Choi, I. Y., & Mun, S. K. (2018). Prostate Clinical Outlook Visualization System for Patients and Clinicians Considering Cyberknife Treatment—A Personalized Approach. Applied Sciences, 8(3), 471. https://doi.org/10.3390/app8030471