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Open AccessFeature PaperReview

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Department of Mining-Metallurgy Engineering and Materials Science & POLYMAT, Faculty of Engineering, University of the Basque Country (UPV/EHU), Bilbao 480130, Spain
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Academic Editor: Jordi Puiggalí
Appl. Sci. 2016, 6(12), 436; https://doi.org/10.3390/app6120436
Received: 27 October 2016 / Revised: 10 December 2016 / Accepted: 12 December 2016 / Published: 16 December 2016
(This article belongs to the Special Issue Biodegradable and Biocompatible Nanoparticles)
Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On the other hand, by simple emulsion-solvent evaporation techniques, microspheres of controlled size and size distribution can be fabricated. The resulting microspheres can be further surface-modified to enhance cell adhesion and proliferation. As a result of this process, biodegradable microcarriers with advanced functionalities and surface properties that can be directly employed as injectable cell microcarriers are obtained. View Full-Text
Keywords: polylactide; poly(α-hydroxyacids); cell microcarriers; microparticles; tissue engineering polylactide; poly(α-hydroxyacids); cell microcarriers; microparticles; tissue engineering
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MDPI and ACS Style

Larrañaga, A.; Sarasua, J.-R. Poly(α-hydroxy Acids)-Based Cell Microcarriers. Appl. Sci. 2016, 6, 436.

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