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Open AccessArticle

Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives

1
Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran
2
Medical Biotechnology Research Center, Guilan University of Medical Sciences, Rasht 4477166595, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Rajender S. Varma
Appl. Sci. 2016, 6(1), 27; https://doi.org/10.3390/app6010027
Received: 13 November 2015 / Revised: 18 December 2015 / Accepted: 29 December 2015 / Published: 19 January 2016
Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry. View Full-Text
Keywords: Alum; bispyrazole derivatives; 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one; Carbonyl compound; Solvent-free conditions Alum; bispyrazole derivatives; 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one; Carbonyl compound; Solvent-free conditions
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MDPI and ACS Style

Zolfigol, M.A.; Khazaei, A.; Karimitabar, F.; Hamidi, M. Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives. Appl. Sci. 2016, 6, 27.

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