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Vibrational Microspectroscopy for Cancer Screening

1
DIT Centre for Radiation and Environmental Science, FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
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School of Physics, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
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FOCAS Research Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
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Author to whom correspondence should be addressed.
Academic Editor: Ken Ledingham
Appl. Sci. 2015, 5(1), 23-35; https://doi.org/10.3390/app5010023
Received: 7 December 2014 / Revised: 5 February 2015 / Accepted: 10 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Casting Light on Cancer Therapy)
Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) spectroscopy is a complementary vibrational spectroscopic technique based on the absorption of IR radiation by the sample. Molecules absorb specific frequencies of the incident light which are characteristic of their structure. IR and Raman spectroscopy are sensitive to subtle biochemical changes occurring at the molecular level allowing spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports demonstrating the potential of IR and Raman spectroscopy together with multivariate statistical analysis techniques for the detection of a variety of cancers including, breast, lung, brain, colon, oral, oesophageal, prostate and cervical cancer. This paper discusses the recent advances and the future perspectives in relation to cancer screening applications, focussing on cervical and oral cancer. View Full-Text
Keywords: optical diagnosis; lasers; Raman spectroscopy; FTIR spectroscopy; cervical cancer; oral cancer; screening; cytology optical diagnosis; lasers; Raman spectroscopy; FTIR spectroscopy; cervical cancer; oral cancer; screening; cytology
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MDPI and ACS Style

Lyng, F.M.; Ramos, I.R.M.; Ibrahim, O.; Byrne, H.J. Vibrational Microspectroscopy for Cancer Screening. Appl. Sci. 2015, 5, 23-35.

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