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Applied Sciences
Volume 15
Issue 18
10.3390/app15189997
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Modern Honey-Based Delivery Systems for Wound Healing: A Review of Current Trends and Future Perspectives

by
Anna Gościniak
1,
Everaldo Attard
2,
Ida Judyta Malesza
3,
Adam Kamiński
4 and
Judyta Cielecka-Piontek
1,*
1
Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 60-806 Poznan, Poland
2
Division of Rural Sciences and Food Systems, Institute of Earth Systems, University of Malta, MSD 2080 Msida, Malta
3
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland
4
Department of Orthopedics and Traumatology, Independent Public Clinical Hospital No. 1, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(18), 9997; https://doi.org/10.3390/app15189997
Submission received: 19 August 2025 / Revised: 8 September 2025 / Accepted: 11 September 2025 / Published: 12 September 2025
(This article belongs to the Special Issue New Advances in Antioxidant Properties of Bee Products)
Versions Notes

Abstract

Honey is a multifunctional therapeutic agent in wound management with antimicrobial, anti-inflammatory, antioxidant and tissue-regenerative properties. Direct application is limited by high viscosity, variability in composition and instability of bioactive compounds. Advances in biomaterials engineering have enabled the development of honey-based delivery platforms such as nanoparticles, electrospun nanofibers and hydrogels, which improve stability, retention at the wound site and provide controlled release. The review offers a comprehensive overview of honey’s wound-healing mechanisms, evaluates diverse delivery strategies and compares their structural and functional characteristics. Nanoparticles enable targeted delivery and synergistic antimicrobial effects, electrospun mats mimic the extracellular matrix with tunable porosity and hydrogels maintain a moist healing environment with high adaptability. Key challenges include achieving standardization, enhancing mechanical properties and optimizing sterilization methods. Future perspectives emphasize integrating honey-based systems with smart sensors, advanced bioprinting and multifunctional composites to achieve personalized and responsive wound care.
Keywords: wound healing; delivery systems; electrospinning; nanoparticles; hydrogels wound healing; delivery systems; electrospinning; nanoparticles; hydrogels

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MDPI and ACS Style

Gościniak, A.; Attard, E.; Malesza, I.J.; Kamiński, A.; Cielecka-Piontek, J. Modern Honey-Based Delivery Systems for Wound Healing: A Review of Current Trends and Future Perspectives. Appl. Sci. 2025, 15, 9997. https://doi.org/10.3390/app15189997

AMA Style

Gościniak A, Attard E, Malesza IJ, Kamiński A, Cielecka-Piontek J. Modern Honey-Based Delivery Systems for Wound Healing: A Review of Current Trends and Future Perspectives. Applied Sciences. 2025; 15(18):9997. https://doi.org/10.3390/app15189997

Chicago/Turabian Style

Gościniak, Anna, Everaldo Attard, Ida Judyta Malesza, Adam Kamiński, and Judyta Cielecka-Piontek. 2025. "Modern Honey-Based Delivery Systems for Wound Healing: A Review of Current Trends and Future Perspectives" Applied Sciences 15, no. 18: 9997. https://doi.org/10.3390/app15189997

APA Style

Gościniak, A., Attard, E., Malesza, I. J., Kamiński, A., & Cielecka-Piontek, J. (2025). Modern Honey-Based Delivery Systems for Wound Healing: A Review of Current Trends and Future Perspectives. Applied Sciences, 15(18), 9997. https://doi.org/10.3390/app15189997

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