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Volume 12
Issue 9
10.3390/app12094430
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Article

Design and Implementation of Anatomically Inspired Mesenteric and Intestinal Vascular Patterns for Personalized 3D Bioprinting

by
Rachel Cadle
1,
Dan Rogozea
2,
Leni Moldovan
3 and
Nicanor I. Moldovan
2,*
1
Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University–Purdue University Indianapolis, Indianapolis, IN 46202, USA
2
3D Tissue Bioprinting Core Laboratory, Indiana Institute for Medical Research, Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA
3
Department of Surgery, IU School of Medicine, Indianapolis, IN 46202, USA
*
Author to whom correspondence should be addressed.
Appl. Sci. 2022, 12(9), 4430; https://doi.org/10.3390/app12094430
Submission received: 21 March 2022 / Revised: 11 April 2022 / Accepted: 19 April 2022 / Published: 27 April 2022
(This article belongs to the Special Issue 3D Bioprinted Tissues for Personalized Medicine Approaches)
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Abstract

Recent progress in bioprinting has made possible the creation of complex 3D intestinal constructs, including vascularized villi. However, for their integration into functional units useful for experimentation or implantation, the next challenge is to endow them with a larger-scale, anatomically realistic vasculature. In general, the perfusion of bioprinted constructs has remained difficult, and the current solution is to provide them with mostly linear and simply branched channels. To address this limitation, here we demonstrated an image analysis-based workflow leading through computer-assisted design from anatomic images of rodent mesentery and colon to the actual printing of such patterns with paste and hydrogel bioinks. Moreover, we reverse-engineered the 2D intestinal image-derived designs into cylindrical objects, and 3D-printed them in a support hydrogel. These results open the path towards generation of more realistically vascularized tissue constructs for a variety of personalized medicine applications.
Keywords: 3D bioprinting; image analysis; vasculature; personalized; intestine; mesentery; FRESH bioprinting 3D bioprinting; image analysis; vasculature; personalized; intestine; mesentery; FRESH bioprinting

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MDPI and ACS Style

Cadle, R.; Rogozea, D.; Moldovan, L.; Moldovan, N.I. Design and Implementation of Anatomically Inspired Mesenteric and Intestinal Vascular Patterns for Personalized 3D Bioprinting. Appl. Sci. 2022, 12, 4430. https://doi.org/10.3390/app12094430

AMA Style

Cadle R, Rogozea D, Moldovan L, Moldovan NI. Design and Implementation of Anatomically Inspired Mesenteric and Intestinal Vascular Patterns for Personalized 3D Bioprinting. Applied Sciences. 2022; 12(9):4430. https://doi.org/10.3390/app12094430

Chicago/Turabian Style

Cadle, Rachel, Dan Rogozea, Leni Moldovan, and Nicanor I. Moldovan. 2022. "Design and Implementation of Anatomically Inspired Mesenteric and Intestinal Vascular Patterns for Personalized 3D Bioprinting" Applied Sciences 12, no. 9: 4430. https://doi.org/10.3390/app12094430

APA Style

Cadle, R., Rogozea, D., Moldovan, L., & Moldovan, N. I. (2022). Design and Implementation of Anatomically Inspired Mesenteric and Intestinal Vascular Patterns for Personalized 3D Bioprinting. Applied Sciences, 12(9), 4430. https://doi.org/10.3390/app12094430

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