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Article

Creating a Novel Mathematical Model of the Kv10.1 Ion Channel and Controlling Channel Activity with Nanoelectromechanical Systems

1
Institute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, A-8010 Graz, Austria
2
Innovation Center of the Faculty of Mechanical Engineering, University of Belgrade, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Academic Editors: Luis Gracia and Carlos Perez-Vidal
Appl. Sci. 2022, 12(8), 3836; https://doi.org/10.3390/app12083836
Received: 14 March 2022 / Revised: 8 April 2022 / Accepted: 8 April 2022 / Published: 11 April 2022
(This article belongs to the Special Issue Trends and Challenges in Robotic Applications)
The use of nanoelectromechanical systems or nanorobots offers a new concept for sensing and controlling subcellular structures, such as ion channels. We present here a novel method for mathematical modeling of ion channels based on control system theory and system identification. We investigated the use of nanoelectromechanical devices to control the activity of ion channels, particularly the activity of the voltage-gated ion channel Kv10.1, an important channel in cancer development and progression. A mathematical model of the dynamic behavior of the selected ion channel Kv10.1 in the Laplace (s) domain was developed, which is given in the representation of a transfer function. In addition, we addressed the possibilities of controlling ion channel activity by nanoelectromechanical devices and nanorobots and finally presented a control algorithm for the Kv10.1 as a control object. A use case demonstrates the potential of a Kv10.1 controlled nanorobot for cancer treatment at a single-cell level. View Full-Text
Keywords: nanoelectromechanical system (NEMS); nanorobots; ion channel Kv10.1; mathematical modeling; system identification; control algorithm nanoelectromechanical system (NEMS); nanorobots; ion channel Kv10.1; mathematical modeling; system identification; control algorithm
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MDPI and ACS Style

Lozanović Šajić, J.; Langthaler, S.; Baumgartner, C. Creating a Novel Mathematical Model of the Kv10.1 Ion Channel and Controlling Channel Activity with Nanoelectromechanical Systems. Appl. Sci. 2022, 12, 3836. https://doi.org/10.3390/app12083836

AMA Style

Lozanović Šajić J, Langthaler S, Baumgartner C. Creating a Novel Mathematical Model of the Kv10.1 Ion Channel and Controlling Channel Activity with Nanoelectromechanical Systems. Applied Sciences. 2022; 12(8):3836. https://doi.org/10.3390/app12083836

Chicago/Turabian Style

Lozanović Šajić, Jasmina, Sonja Langthaler, and Christian Baumgartner. 2022. "Creating a Novel Mathematical Model of the Kv10.1 Ion Channel and Controlling Channel Activity with Nanoelectromechanical Systems" Applied Sciences 12, no. 8: 3836. https://doi.org/10.3390/app12083836

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