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Tissue Engineering Strategies for Retina Regeneration

1
Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
2
Departments of Physical Medicine & Rehabilitation, Ophthalmology, Anatomy & Neurobiology, Sue and Bill Gross Stem Cell Research Centre, University of California, Irvine, CA 92697-1705, USA
3
Department of Physics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
4
USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ioana Chiulan 
Appl. Sci. 2021, 11(5), 2154; https://doi.org/10.3390/app11052154
Received: 6 February 2021 / Revised: 22 February 2021 / Accepted: 23 February 2021 / Published: 28 February 2021
(This article belongs to the Special Issue Biomaterials, Polymers and Tissue Engineering)
The retina is a complex and fragile photosensitive part of the central nervous system which is prone to degenerative diseases leading to permanent vision loss. No proven treatment strategies exist to treat or reverse the degenerative conditions. Recent investigations demonstrate that cell transplantation therapies to replace the dysfunctional retinal pigment epithelial (RPE) cells and or the degenerating photoreceptors (PRs) are viable options to restore vision. Pluripotent stem cells, retinal progenitor cells, and somatic stem cells are the main cell sources used for cell transplantation therapies. The success of retinal transplantation based on cell suspension injection is hindered by limited cell survival and lack of cellular integration. Recent advances in material science helped to develop strategies to grow cells as intact monolayers or as sheets on biomaterial scaffolds for transplantation into the eyes. Such implants are found to be more promising than the bolus injection approach. Tissue engineering techniques are specifically designed to construct biodegradable or non-degradable polymer scaffolds to grow cells as a monolayer and construct implantable grafts. The engineered cell construct along with the extracellular matrix formed, can hold the cells in place to enable easy survival, better integration, and improved visual function. This article reviews the advances in the use of scaffolds for transplantation studies in animal models and their application in current clinical trials. View Full-Text
Keywords: retinal degenerative diseases; age-related macular degeneration; biomaterials; stem cells; retinal pigment epithelium; tissue engineering retinal degenerative diseases; age-related macular degeneration; biomaterials; stem cells; retinal pigment epithelium; tissue engineering
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MDPI and ACS Style

Rajendran Nair, D.S.; Seiler, M.J.; Patel, K.H.; Thomas, V.; Martinez Camarillo, J.C.; Humayun, M.S.; Thomas, B.B. Tissue Engineering Strategies for Retina Regeneration. Appl. Sci. 2021, 11, 2154. https://doi.org/10.3390/app11052154

AMA Style

Rajendran Nair DS, Seiler MJ, Patel KH, Thomas V, Martinez Camarillo JC, Humayun MS, Thomas BB. Tissue Engineering Strategies for Retina Regeneration. Applied Sciences. 2021; 11(5):2154. https://doi.org/10.3390/app11052154

Chicago/Turabian Style

Rajendran Nair, Deepthi S., Magdalene J. Seiler, Kahini H. Patel, Vinoy Thomas, Juan Carlos Martinez Camarillo, Mark S. Humayun, and Biju B. Thomas. 2021. "Tissue Engineering Strategies for Retina Regeneration" Applied Sciences 11, no. 5: 2154. https://doi.org/10.3390/app11052154

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