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Comparative Phytochemical Analysis of Syzygium formosum (Wall.) Masam Leaf and Its Biological Activities

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Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Korea
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CarboExpert Inc., 705, Building W1, #99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
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Faculty of Biotechnology, Binh Duong University, Thu Dau Mot 820000, Vietnam
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Department of Food Science and Technology, Chungnam National University, Daejeon 34134, Korea
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Authors to whom correspondence should be addressed.
Academic Editor: Luca Mazzoni
Appl. Sci. 2021, 11(22), 10552; https://doi.org/10.3390/app112210552
Received: 20 October 2021 / Revised: 31 October 2021 / Accepted: 3 November 2021 / Published: 9 November 2021
Syzygium formosum (SF) leaves have long been used in traditional medicine for the treatment of skin-related diseases such as atopic dermatitis and psoriasis. To understand the underpinning pharmacological mechanism of skin relief functionality, the quantitative profile of phytochemicals in the leaf extract has been performed. Twenty phytochemical components including eight flavonoids, three phenolic acids, and nine triterpenoids were identified and quantitatively analyzed from the SF leaves. The dominant flavonoids of the SF leaves were found to be catechin and myricetin-3-O-rhamnoside. Gallic acid was the most abundant phenolic acid. Among triterpenoids, asiatic acid, corosolic acid, and betulinic acid exhibited a high concentration ranging 2.78–8.59, 3.19–3.91, and 3.58–6.14 mg/g dry leaf, respectively. The total triterpenoid contents were 14.18–19.00 mg/g dry leaf which were 3-fold higher than those in the Indonesian Centella asiatica leaves. In human keratinocytes assay, industrial scale extract of SF significantly reduced expressions of proinflammatory cytokines and cyclooxygenase-2. Furthermore, that SF extract exhibited very strong antibacterial activity on Staphylococcus aureus and Cutibacterium acnes that possibly induce serious skin problems. Our results proved that S. formosum leaf extract with high content of biologically active compounds could be a superior bioactive ingredient in cosmetic and pharmaceutical products. View Full-Text
Keywords: Syzygium formosum; phytochemicals; triterpenoids; phenolic compounds; anti-inflammation; antibacterial activity Syzygium formosum; phytochemicals; triterpenoids; phenolic compounds; anti-inflammation; antibacterial activity
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MDPI and ACS Style

Hoang, K.H.T.; Lim, J.; Nguyen, M.T.T.; Lee, N.-Y.; Lee, C.-K.; Nguyen, V.D.; Kim, H.-L.; Park, J.-T.; Kim, J. Comparative Phytochemical Analysis of Syzygium formosum (Wall.) Masam Leaf and Its Biological Activities. Appl. Sci. 2021, 11, 10552. https://doi.org/10.3390/app112210552

AMA Style

Hoang KHT, Lim J, Nguyen MTT, Lee N-Y, Lee C-K, Nguyen VD, Kim H-L, Park J-T, Kim J. Comparative Phytochemical Analysis of Syzygium formosum (Wall.) Masam Leaf and Its Biological Activities. Applied Sciences. 2021; 11(22):10552. https://doi.org/10.3390/app112210552

Chicago/Turabian Style

Hoang, Khanh H.T., Jaeyoon Lim, My T.T. Nguyen, Nan-Young Lee, Chang-Kyu Lee, Van D. Nguyen, Hye-Lynn Kim, Jong-Tae Park, and Jaehan Kim. 2021. "Comparative Phytochemical Analysis of Syzygium formosum (Wall.) Masam Leaf and Its Biological Activities" Applied Sciences 11, no. 22: 10552. https://doi.org/10.3390/app112210552

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