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Open AccessReview

Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis

1
School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, UK
2
Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(7), 2244; https://doi.org/10.3390/app10072244 (registering DOI)
Received: 2 March 2020 / Revised: 19 March 2020 / Accepted: 24 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Implantable Medical Device)
Osteomyelitis is a devasting disease caused by the infection of bone tissue and is associated with significant morbidity and mortality. It is treated with antibiotic therapy and surgical debridement. A high dose of systemic antibiotics is often required due to poor bone penetration and this is often associated with unacceptable side-effects. To overcome this, local, implantable antibiotic carriers such as polymethyl methacrylate have been developed. However, this is a non-biodegradable material that requires a second surgery to be removed. As a result, attention has shifted to new antibiotic-eluting scaffolds which can be created with a range of unique properties. The purpose of this review is to assess the level of evidence that exists for these novel local treatments. Although this field is still developing, these strategies seem promising and provide hope for the future treatment of chronic osteomyelitis. View Full-Text
Keywords: antibiotic; scaffold; bone substitute; bone graft; osteomyelitis; orthopaedics antibiotic; scaffold; bone substitute; bone graft; osteomyelitis; orthopaedics
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MDPI and ACS Style

Kyriacou, H.; Kamaraj, A.; Khan, W.S. Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis. Appl. Sci. 2020, 10, 2244.

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