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Open AccessReview

Vascularized Lower Respiratory-Physiology-On-A-Chip

by Hyoryung Nam 1,†, Yoo-mi Choi 1,† and Jinah Jang 1,2,3,4,*
1
Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
2
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
3
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
4
Institute of Convergence Science, Yonsei University, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Appl. Sci. 2020, 10(3), 900; https://doi.org/10.3390/app10030900
Received: 15 December 2019 / Revised: 12 January 2020 / Accepted: 23 January 2020 / Published: 30 January 2020
(This article belongs to the Special Issue Biomaterials and Biofabrication)
Recently, respiratory systems are increasingly threatened by high levels of environmental pollution. Organ-on-a-chip technology has the advantage of enabling more accurate preclinical experiments by reproducing in vivo organ physiology. To investigate disease mechanisms and treatment options, respiratory-physiology-on-a-chip systems have been studied for the last decade. Here, we delineate the strategic approaches to develop respiratory-physiology-on-a-chip that can recapitulate respiratory system in vitro. The state-of-the-art biofabrication methods and biomaterials are considered as key contributions to constructing the chips. We also explore the vascularization strategies to investigate complicated pathophysiological phenomena including inflammation and immune responses, which are the critical aggravating factors causing the complications in the respiratory diseases. In addition, challenges and future research directions are delineated to improve the mimicry of respiratory systems in terms of both structural and biological behaviors. View Full-Text
Keywords: respiratory system; organ-on-a-chip; vascularization; biofabrication; extracellular matrix respiratory system; organ-on-a-chip; vascularization; biofabrication; extracellular matrix
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MDPI and ACS Style

Nam, H.; Choi, Y.-M.; Jang, J. Vascularized Lower Respiratory-Physiology-On-A-Chip. Appl. Sci. 2020, 10, 900.

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