Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Evaluation of Salivary and Serum MPO
2.3. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Controls (N = 31) | Periodontitis (N = 31) | CVD (N = 31) | Periodontitis + CVD (N = 31) | |
---|---|---|---|---|
Age (years) | 52 (48; 56) | 53 (47; 57) | 52 (46; 58) | 53 (47; 56) |
Gender (male/female) | 15/16 | 16/15 | 14/17 | 16/15 |
Education level | ||||
Primary school, n (%) | 11 (35.4) | 12 (38.7) | 11 (35.4) | 12 (38.7) |
High school, n (%) | 14 (45.1) | 13 (41.9) | 15 (48.3) | 14 (45.1) |
College/university, n (%) | 6 (19.3) | 6 (19.3) | 5 (16.1) | 5 (16.1) |
Body mass index (kg/m2) | 24.4 (21.8; 27.8) | 23.9 (22.4; 26.4) | 24.8 (21.6; 27.1) | 24.5 (22.3; 26.1) |
Fasting glucose (mg/dl) | 87.9 (82.1; 93.2) | 88.7 (82.3; 105.3) | 88.1 (80.6; 114.6) | 91.1 (85.1; 109.2) |
Smokers, n (%) | 2 (6.4) | 3 (9.6) | 2 (6.4) | 2 (9.6) |
Never smokers, n (%) | 27 (88.2) | 27 (85.2) | 28 (88.2) | 26 (85.2) |
Past smokers, n (%) | 2 (6.4) | 1 (3.2) | 1 (3.2) | 3 (9.6) |
Current smokers, n (%) | 2 (6.4) | 3 (6.4) | 2 (6.4) | 2 (6.4) |
Comorbidities | ||||
Diabetes, n (%) | - | 3 (9.6) ** | 2 (6.4) ** | 2 (9.6) ** |
Previous CVD | ||||
Atrial fibrillation, n (%) | - | - | 6 (19.3) **,§§ | 5 (16.1) **,§§ |
Angina pectoris, n (%) | - | - | 12 (38.7) **,§§ | 13 (41.9) **,§§ |
Stroke, n (%) | - | - | 5 (16.1) **,§§ | 7 (22.6) **,§§ |
Heart failure, n (%) | - | - | 6 (19.3) **,§§ | 5 (16.1) **,§§ |
Antihypertensive, n (%) | - | - | 10 (32.2) **,§§ | 10 (32.2) **,§§ |
Statins, n (%) | - | - | 10 (32.2) **,§§ | 9 (29) **,§§ |
Low-dose aspirin, n (%) | - | - | 7 (22.6) **,§§ | 7 (22.6) **,§§ |
Beta blockers, n (%) | - | - | 6 (19.3) **,§§ | 8 (25.8) **,§§ |
hs-CRP (mg/L) | 2.5 (2.1; 2.9) | 3.1 (2.5; 3.9) * | 5.6 (4.8; 6.2) ** | 6.7 (5.8; 7.1) **,§§,# |
Total cholesterol (mg/dl) | 162 (139; 181) | 164 (133; 181) | 173 (139; 197) | 176 (178; 201) |
Triglycerids (mg/dl) | 121 (91; 145) | 102 (66; 128) | 141 (122; 166) | 139 (103; 158) |
Controls (N = 31) | Periodontitis (N = 31) | CVD (N = 31) | Periodontitis + CVD (N = 31) | |
---|---|---|---|---|
N° of teeth | 26 (21; 27) | 20 (15; 21)** | 23 (19; 26) **,§§ | 18 (12; 20) **,## |
CAL (mm) | 1 (0.9; 1.3) | 3.6 (3.1; 4.2) ** | 2 (1.8; 2.4) **,§§ | 3.4 (3; 4.1) **,## |
CAL 4–5 mm (% sites) | - | 38.7 (35.4; 42.9) ** | - | 40.6 (35.5; 46.1) **,## |
CAL ≥6 mm (% sites) | - | 18.7 (19.6; 22.3) ** | - | 17.4 (15.8; 22.7) **,## |
PD (mm) | 1.5 (1.3; 1.9) | 4.4 (3.7; 4.6) ** | 2.1 (1.8; 2.4) **,§§ | 3.9 (3.7; 4.4) **,## |
PD 4–5 mm (% sites) | - | 40.9 (38.6; 45.7) ** | - | 44.1 (42.7; 55.3) **,## |
PD ≥6 mm (% sites) | - | 23.1 (19.8; 25.2) ** | - | 22.7 (20.3; 26.5) **,§§,## |
BOP (%) | 7.9 (6.5; 8.3) | 41.2 (34.3; 46.5) ** | 8.1 (6.4; 8.9) **,§§ | 42.3 (41.5; 50.1) **,§§,## |
Rx alveolar bone loss (mm) | 0.2 (0.1; 0.5) | 2.9 (2.5; 3.4) ** | 0.3 (0.2; 0.9) **,§§ | 3.3 (2.1; 4.6) **,## |
PI (%) | 6.5 (4.7; 9.3) | 35.4 (31.7; 37.9) ** | 11.7 (9.1; 12.8) **,§§ | 32.4 (27.2; 36.1) **,## |
Serum MPO Levels | UNIVARIATE | MULTIVARIATE | |||||
---|---|---|---|---|---|---|---|
Variable | B | 95% CI | p | B | 95% CI | p | |
CVD | 0.442 | 0.314; 0.558 | <0.001 | 0.122 | −0.221; 0.559 | 0.578 | |
Periodontitis | 0.289 | 0.18; 0.274 | 0.024 | 0.231 | −0.066; 0.319 | 0.226 | |
hs-CRP | 0.278 | 0.028; 0.136 | <0.001 | 0.314 | 0.065; 0.189 | <0.001 | |
Age (years) | −0.047 | −0.287; 0.056 | 0.064 | −0.039 | −0.111; 0.315 | 0.287 | |
Female gender | 0.212 | −0.78; 0.549 | 0.227 | 0.219 | −0.88; 0.428 | 0.112 | |
Education SES | −0.114 | −0.178; 0.123 | 0.287 | −0.066 | −0.312; 0.398 | 0.312 | |
Salivary MPO Levels | |||||||
CVD | 0.319 | 0.112; 0.552 | <0.001 | −0.065 | −0.412; 0.289 | 0.451 | |
Periodontitis | 0.078 | −0.069; 0.328 | 0.411 | 0.007 | −0.178; 0.213 | 0.665 | |
hs-CRP | 0.082 | 0.027; 0.287 | <0.001 | 0.066 | 0.021; 0.133 | <0.001 | |
Age (years) | −0.051 | −0.110; 0.036 | 0.399 | 0.047 | −0.028; 0.087 | 0.741 | |
Female gender | 0.074 | −0.112; 0.211 | 0.398 | 0.071 | −0.065; 0.412 | 0.321 | |
Total Cholesterol | −0.057 | −0.151; −0.062 | 0.037 | −0.65 | −0.041; 0.314 | 0.035 | |
Serum MPO | 0.122 | −0.021; 0.557 | 0.057 | −0.036 | −0.369; 0.166 | 0.331 |
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Polizzi, A.; Torrisi, S.; Santonocito, S.; Di Stefano, M.; Indelicato, F.; Lo Giudice, A. Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study. Appl. Sci. 2020, 10, 1037. https://doi.org/10.3390/app10031037
Polizzi A, Torrisi S, Santonocito S, Di Stefano M, Indelicato F, Lo Giudice A. Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study. Applied Sciences. 2020; 10(3):1037. https://doi.org/10.3390/app10031037
Chicago/Turabian StylePolizzi, Alessandro, Salvatore Torrisi, Simona Santonocito, Mattia Di Stefano, Francesco Indelicato, and Antonino Lo Giudice. 2020. "Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study" Applied Sciences 10, no. 3: 1037. https://doi.org/10.3390/app10031037
APA StylePolizzi, A., Torrisi, S., Santonocito, S., Di Stefano, M., Indelicato, F., & Lo Giudice, A. (2020). Influence of Myeloperoxidase Levels on Periodontal Disease: An Applied Clinical Study. Applied Sciences, 10(3), 1037. https://doi.org/10.3390/app10031037