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Mosaicplasty versus Matrix-Assisted Autologous Chondrocyte Transplantation for Knee Cartilage Defects: A Long-Term Clinical and Imaging Evaluation
Open AccessArticle

Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee

1
Department of Orthopaedics and Traumatology, Uzsoki Hospital, 1145 Budapest, Hungary
2
MS2 INSIGHT Consulting, LLC, Denver, CO 80220, USA
3
Fluid Analytics Cambridge, Cambridge CB1 8DH, UK
4
Fowler Kennedy Sport Medicine Clinic, University of Western Ontario, London, ON N6A 3K7, Canada
5
Qmetrics Technologies Pittsford, New York, NY 14534, USA
6
Collagen Solutions Plc Eden Prairie, Eden Prairie, MN 55344, USA
7
Nuclear Medicine Uzsoki Hospital, 1145 Budapest, Hungary
8
Department of Traumatology, Semmelweis University, 1085 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Co-First Authors.
Appl. Sci. 2020, 10(16), 5642; https://doi.org/10.3390/app10165642
Received: 7 June 2020 / Revised: 25 July 2020 / Accepted: 11 August 2020 / Published: 14 August 2020
Scaffolds are thought to be a key element needed for successful cartilage repair treatments, and this prospective extension study aimed to evaluate long-term structural and clinical outcomes following osteochondral defect treatment with a cell-free biphasic scaffold. Structural outcomes were assessed using quantitative 3-D magnetic resonance imaging (MRI) and morphological segmentation to determine the percentage of defect filling and repair cartilage T2 relaxation times, and clinical outcomes were determined with the modified Cincinnati Rating System, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Seventeen subjects with osteochondral defects in the knee were treated with ChondroMimetic scaffolds, from which 15 returned for long-term evaluation at a mean follow-up of 7.9 ± 0.3 years. The defects treated were trochlear donor sites for mosaicplasty in 13 subjects, and medial femoral condyle defects in 2 subjects. MRI analysis of scaffold-treated defects found a mean total defect filling of 95.2 ± 3.6%, and a tissue mean T2 relaxation time of 52.5 ± 4.8 ms, which was identical to the T2 of ipsilateral control cartilage (52.3 ± 9.2 ms). The overall modified Cincinnati Rating System score was statistically significant from baseline (p = 0.0065), and KOOS subscales were equivalent to other cartilage repair techniques. ChondroMimetic treatment resulted in a consistently high degree of osteochondral defect filling with durable, cartilage-like repair tissue at 7.9 years, potentially associated with clinical improvement. View Full-Text
Keywords: biphasic scaffold; osteochondral defect; cartilage repair; quantitative MRI; calcium phosphate biphasic scaffold; osteochondral defect; cartilage repair; quantitative MRI; calcium phosphate
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MDPI and ACS Style

Berta, A.; Shive, M.S.; Lynn, A.K.; Getgood, A.; Totterman, S.; Busby, G.; Hollenstein, J.; Vásárhelyi, G.; Kéki, I.; Hangody, L. Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee. Appl. Sci. 2020, 10, 5642.

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