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Article

Effect of Handgrip Strength on Clinical Outcomes of Patients with Hepatocellular Carcinoma Treated with Lenvatinib

1
Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan
2
Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan
3
Department of Medical Education, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(16), 5403; https://doi.org/10.3390/app10165403
Received: 7 July 2020 / Revised: 1 August 2020 / Accepted: 3 August 2020 / Published: 5 August 2020
(This article belongs to the Special Issue Treatment Strategies for Hepatocellular Carcinoma)
Previous studies have reported prognostic factors for hepatocellular carcinoma (HCC) patients receiving lenvatinib; however, no studies have evaluated the effects of both handgrip strength and skeletal muscle mass on the clinical outcomes. Therefore, this retrospective study investigated the individual effect of handgrip strength, skeletal muscle mass, and sarcopenia on clinical outcomes of 53 HCC patients treated with lenvatinib. Before receiving lenvatinib, handgrip strength and skeletal muscle index (SMI) were measured. Low handgrip strength and muscle depletion were defined as <26 and <18 kg and SMI <42 and SMI <38 cm2/m2 in men and women, respectively. Sarcopenia was defined as having low handgrip strength and muscle depletion. Multivariate analysis identified modified albumin–bilirubin grade 1–2a (p = 0.010), Barcelona Clinic Liver Cancer stage A–B (p = 0.011), and absence of low handgrip strength (p = 0.015) as favorable prognostic factors for survival. Furthermore, sarcopenia was an independent significant prognostic factor for survival. Time to treatment failure was associated with handgrip strength and sarcopenia. Our findings suggest that handgrip strength may be a useful marker of clinical outcomes in HCC patients treated with lenvatinib. View Full-Text
Keywords: hepatocellular carcinoma; handgrip strength; lenvatinib; skeletal muscle; survival; time to treatment failure hepatocellular carcinoma; handgrip strength; lenvatinib; skeletal muscle; survival; time to treatment failure
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MDPI and ACS Style

Kotoh, Y.; Saeki, I.; Yamasaki, T.; Sasaki, R.; Tanabe, N.; Oono, T.; Matsuda, T.; Hisanaga, T.; Matsumoto, T.; Hidaka, I.; Ishikawa, T.; Takami, T.; Sakaida, I. Effect of Handgrip Strength on Clinical Outcomes of Patients with Hepatocellular Carcinoma Treated with Lenvatinib. Appl. Sci. 2020, 10, 5403. https://doi.org/10.3390/app10165403

AMA Style

Kotoh Y, Saeki I, Yamasaki T, Sasaki R, Tanabe N, Oono T, Matsuda T, Hisanaga T, Matsumoto T, Hidaka I, Ishikawa T, Takami T, Sakaida I. Effect of Handgrip Strength on Clinical Outcomes of Patients with Hepatocellular Carcinoma Treated with Lenvatinib. Applied Sciences. 2020; 10(16):5403. https://doi.org/10.3390/app10165403

Chicago/Turabian Style

Kotoh, Yurika, Issei Saeki, Takahiro Yamasaki, Ryo Sasaki, Norikazu Tanabe, Takashi Oono, Takashi Matsuda, Takuro Hisanaga, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, and Isao Sakaida. 2020. "Effect of Handgrip Strength on Clinical Outcomes of Patients with Hepatocellular Carcinoma Treated with Lenvatinib" Applied Sciences 10, no. 16: 5403. https://doi.org/10.3390/app10165403

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